Bamipine

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MedKoo CAT#: 585201

CAS#: 4945-47-5

Description: Bamipine is a compound with H1 antihistamine with anticholinergic properties.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-26. Prices are subject to change without notice.

Bamipine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 585201
Name: Bamipine
CAS#: 4945-47-5
Chemical Formula: C19H24N2
Exact Mass: 280.1939
Molecular Weight: 280.415
Elemental Analysis: C, 81.38; H, 8.63; N, 9.99


Synonym: Bamipine; Soventol; Tamidrine

IUPAC/Chemical Name: Piperidine, 4-(N-benzyl-N-phenylamino)-1-methyl-

InChi Key: VZSXTYKGYWISGQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H24N2/c1-20-14-12-19(13-15-20)21(18-10-6-3-7-11-18)16-17-8-4-2-5-9-17/h2-11,19H,12-16H2,1H3

SMILES Code: CN1CCC(N(CC2=CC=CC=C2)C3=CC=CC=C3)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Biryol I, Kabasakaloğlu M, Sentürk Z. Investigation of the mechanism of the electrochemical oxidation of bamipine hydrochloride by voltammetry. Analyst. 1989 Feb;114(2):181-4. PubMed PMID: 2712317.

2: Neidlein R, Kleiser M. [Biotransformation and pharmacokinetics of bamipine in rats. 1. biotransformation]. Arzneimittelforschung. 1987 Jan;37(1):32-7. German. PubMed PMID: 3566854.

3: GILLHESPY RO, MUSTARD DM. The value of biperiden alone and in combination with bamipine in the treatment of Parkinson's disease. Br J Clin Pract. 1963 Jun;17:345-6. PubMed PMID: 13947925.

4: Neidlein VR, Kleiser M. [Biotransformation and pharmacokinetics of bamipine in rats. 2. Studies of the pharmacokinetics (1.)]. Arzneimittelforschung. 1987 Feb;37(2):174-7. German. PubMed PMID: 2883979.

5: Kountourellis JE, Raptouli A, Georgakopoulos PP. Simultaneous determination of bromochlorosalicylanilide and bamipine in pharmaceutical formulations by high-performance liquid chromatography. J Chromatogr. 1986 Jul 25;362(3):439-42. PubMed PMID: 3760051.

6: Weis R, Schweiger K, Faist J, Rajkovic E, Kungl AJ, Fabian WM, Schunack W, Seebacher W. Antimycobacterial and H1-antihistaminic activity of 2-substituted piperidine derivatives. Bioorg Med Chem. 2008 Dec 15;16(24):10326-31. doi: 10.1016/j.bmc.2008.10.042. Epub 2008 Oct 22. PubMed PMID: 18977145.

7: Sasse BC, Mach UR, Leppaenen J, Calmels T, Stark H. Hybrid approach for the design of highly affine and selective dopamine D(3) receptor ligands using privileged scaffolds of biogenic amine GPCR ligands. Bioorg Med Chem. 2007 Dec 1;15(23):7258-73. Epub 2007 Aug 25. PubMed PMID: 17826096.

8: Neidlein R, Kleiser M. [Biotransformation and pharmacokinetics of bamipine in rats. 2. Pharmacokinetics (P 2)]. Arzneimittelforschung. 1987 Mar;37(3):337-9. German. PubMed PMID: 3593448.

9: Barary MH, Abdel-Hamid ME, Korany MA. Fluorimetric and colorimetric determination of bamipine hydrochloride and its tablets. Pharmazie. 1984 Oct;39(10):706. PubMed PMID: 6522452.

10: Kreiskott H, Hofmann HP. [Central and peripheral interactions of the antiparkinson agent biperiden and the antihistaminic bamipin on the rat excited by pilocarpine]. Arzneimittelforschung. 1978;28(9):1509-11. German. PubMed PMID: 38811.

11: Pommerenke EW, Osswald H, Hahn EW, Volm M. Activity of various amphiphilic agents in reversing multidrug resistance of L 1210 cells. Cancer Lett. 1990 Nov 19;55(1):17-23. PubMed PMID: 2245406.

12: HANNA C. Toxicologic studies on Soventol (N-benzyl-N-phenyl-4-amino-1-methylpiperidine). Toxicol Appl Pharmacol. 1961 Jul;3:393-401. PubMed PMID: 13711269.

13: KWOCZEK J, SCHAEFER R. [Soventol jelly in industrial hygiene]. Munch Med Wochenschr. 1956 Aug 24;98(34):1120-1. German. PubMed PMID: 13358703.

14: FREY JG. [Radioprotection of skin with soventol jelly]. Ther Ggw. 1955 Jul;94(7):255-7. German. PubMed PMID: 13267858.

15: DUSKE A. [Experimental studies on the action mechanism of the antipruriginous effects of soventol gel]. Z Haut Geschlechtskr. 1953 Aug 15;15(4):105-10. Undetermined Language. PubMed PMID: 13103276.

16: GATZEK H, MECHELKE K. [An examination of the capacity of certain antagonists (theophorin, luvistin, avil and soventol) to inhibit the effects of histamine on the circulation of normal man, using a method of continuous registration]. Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1950;211(5):438-40. Undetermined Language. PubMed PMID: 14800311.

17: FREYVOGEL H. [Local treatment of various dermatoses with soventol jelly]. Dermatol Wochenschr. 1954;130(34):899-902. German. PubMed PMID: 13200134.

18: ZIERZ P, PFLANZ C. [Soventol in clinical dermatology]. Dtsch Med Wochenschr. 1950 Nov 3;75(44):1476. Undetermined Language. PubMed PMID: 14793159.

19: TARAB S. [Clinical experience with antiallergikum soventol]. Ther Umsch. 1955 Jun;12(3):53-5. German. PubMed PMID: 13247238.

20: RUTHER H, WIEHL R. [Bromsalicyl-chloranilid-soventol in therapy of refractory epidermophytosis]. Z Haut Geschlechtskr. 1955 Jan 15;18(2):47-50. German. PubMed PMID: 14360222.