GHRP-6 acetate
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MedKoo CAT#: 574018

CAS#: 145177-42-0

Description: GHRP-6 acetate is a synthetic growth hormone (GH) secretagogue and an agonist of the GH secretagogue receptor (GHS-R), which is also known as the ghrelin receptor. It inhibits binding of the GHS-R agonist MK-0677 (Ibutamoren) to COS-7 cell membranes expressing human GHS-R type Ia and binding of ghrelin to COS-7 cells expressing human GHS-R. GHRP-6 stimulates intracellular calcium mobilization in BHK cells expressing the human receptor and inositol phosphate production in COS-7 cells expressing the human receptor. It also acts as a negative allosteric modulator of ghrelin signaling. GHRP-6 induces release of GH, but not thyroid-stimulating hormone (TSH), luteinizing hormone (LH), or follicle-stimulating hormone (FSH), in isolated rat pituitary gland. It increases levels of GH, but not TSH, LH, FSH, or prolactin, in rat blood when administered subcutaneously at a dose of 50 μg. GHRP-6 increases food intake in rats when administered intracerebroventricularly at 0.3, 1, and 3 nmol.

Chemical Structure

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GHRP-6 acetate
CAS# 145177-42-0
Instruction

Theoretical Analysis

MedKoo Cat#: 574018
Name: GHRP-6 acetate
CAS#: 145177-42-0
Chemical Formula: C52H68N12O12
Exact Mass: 1,052.51
Molecular Weight: 1,053.190
Elemental Analysis: C, 59.30; H, 6.51; N, 15.96; O, 18.23

Price and Availability

Size Price Availability Quantity
5mg USD 245
10mg USD 410
50mg USD 905
100mg USD 1750
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Synonym: GHRP-6 acetate, Growth hormone releasing peptide 6 acetate, Hexapeptide-2, HWAWFK-NH2, SKF 110679, U 75799E

IUPAC/Chemical Name: L-histidyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamide, triacetate

InChi Key: XGWOPQAMQAZCJE-SLBOMMQWSA-N

InChi Code: InChI=1S/C46H56N12O6.3C2H4O2/c1-27(54-44(62)39(20-29-23-51-35-15-7-5-13-32(29)35)57-43(61)34(48)22-31-25-50-26-53-31)42(60)56-40(21-30-24-52-36-16-8-6-14-33(30)36)46(64)58-38(19-28-11-3-2-4-12-28)45(63)55-37(41(49)59)17-9-10-18-47;3*1-2(3)4/h2-8,11-16,23-27,34,37-40,51-52H,9-10,17-22,47-48H2,1H3,(H2,49,59)(H,50,53)(H,54,62)(H,55,63)(H,56,60)(H,57,61)(H,58,64);3*1H3,(H,3,4)/t27-,34-,37-,38+,39+,40-;;;/m0.../s1

SMILES Code: O=C(N[C@H](CC1=CC=CC=C1)C(N[C@H](C(N)=O)CCCCN)=O)[C@@H](NC([C@H](C)NC([C@H](NC([C@H](CC2=CN=CN2)N)=O)CC3=CNC4=C3C=CC=C4)=O)=O)CC5=CNC6=C5C=CC=C6.CC(O)=O.CC(O)=O.CC(O)=O

Appearance: A crystalline solid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 1,053.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Bowers, C.Y., Momany, F.A., Reynolds, G.A., et al. On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114(5), 1537-1545 (1984).

2. Howard, A.D., Feighner, S.D., Cully, D.F., et al. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273(5277), 974-977 (1996).

3. Holst, B., Brandt, E., Bach, A., et al. Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling. Mol. Endocrinol. 19(9), 2400-2411 (2005).

4. Wren, A.M., Small, C.J., Ward, H.L., et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 141(11), 4325-4328 (2000).