WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 574012

CAS#: 114014-15-2

Description: Z-Phe-Tyr(tBu)-diazomethylketone is an inhibitor of cathepsin L. It is selective for cathepsin L over cathepsin S and cathepsin B. Z-Phe-Tyr(tBu)-diazomethylketone is active against bloodstream forms of T. brucei brucei clone 427-221a in vitro.

Chemical Structure

CAS# 114014-15-2

Theoretical Analysis

MedKoo Cat#: 574012
Name: Z-Phe-Tyr(tBu)-diazomethylketone
CAS#: 114014-15-2
Chemical Formula: C31H34N4O5
Exact Mass: 542.2529
Molecular Weight: 542.64
Elemental Analysis: C, 68.62; H, 6.32; N, 10.33; O, 14.74

Price and Availability

Size Price Availability Quantity
1.0mg USD 220.0 2 Weeks
5.0mg USD 405.0 2 Weeks
10.0mg USD 660.0 2 Weeks
25.0mg USD 1200.0 2 Weeks
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Synonym: Cbz-Phe-Tyr(O-t-Bu)-CHN2, Z-Phe-Tyr(tBu)-diazomethylketone, Z-Phe-Tyr(tBu)-CHN2

IUPAC/Chemical Name: N-[(1S)-2-[[(1S)-3-diazo-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester


InChi Code: InChI=1S/C31H34N4O5/c1-31(2,3)40-25-16-14-23(15-17-25)18-26(28(36)20-33-32)34-29(37)27(19-22-10-6-4-7-11-22)35-30(38)39-21-24-12-8-5-9-13-24/h4-17,20,26-27H,18-19,21H2,1-3H3,(H,34,37)(H,35,38)/t26-,27-/m0/s1

SMILES Code: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(C=[N+]=[N-])=O)CC2=CC=C(OC(C)(C)C)C=C2)=O)OCC3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 542.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Shaw, E., Mohanty, S., Colic, A., et al. The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpain. FEBS Lett. 334(3), 340-342 (1993).

2. Kirschke, H., Wikstrom, P., and Shaw, E. Active center differences between cathepsins L and B: The S1 binding region. FEBS Lett. 228(1), 128-130 (1988).

3. Nkemngu, N.J., Grande, R., Hansell, E., et al. Improved trypanocidal activities of cathepsin L inhibitors. Int. J. Antimicrob. Agents 22(2), 155-159 (2003).