WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 574012
CAS#: 114014-15-2
Description: Z-Phe-Tyr(tBu)-diazomethylketone is an inhibitor of cathepsin L. It is selective for cathepsin L over cathepsin S and cathepsin B. Z-Phe-Tyr(tBu)-diazomethylketone is active against bloodstream forms of T. brucei brucei clone 427-221a in vitro.
MedKoo Cat#: 574012
Name: Z-Phe-Tyr(tBu)-diazomethylketone
CAS#: 114014-15-2
Chemical Formula: C31H34N4O5
Exact Mass: 542.2529
Molecular Weight: 542.64
Elemental Analysis: C, 68.62; H, 6.32; N, 10.33; O, 14.74
Synonym: Cbz-Phe-Tyr(O-t-Bu)-CHN2, Z-Phe-Tyr(tBu)-diazomethylketone, Z-Phe-Tyr(tBu)-CHN2
IUPAC/Chemical Name: N-[(1S)-2-[[(1S)-3-diazo-1-[[4-(1,1-dimethylethoxy)phenyl]methyl]-2-oxopropyl]amino]-2-oxo-1-(phenylmethyl)ethyl]-carbamic acid, phenylmethyl ester
InChi Key: CGONKNHDBTYOOC-SVBPBHIXSA-N
InChi Code: InChI=1S/C31H34N4O5/c1-31(2,3)40-25-16-14-23(15-17-25)18-26(28(36)20-33-32)34-29(37)27(19-22-10-6-4-7-11-22)35-30(38)39-21-24-12-8-5-9-13-24/h4-17,20,26-27H,18-19,21H2,1-3H3,(H,34,37)(H,35,38)/t26-,27-/m0/s1
SMILES Code: O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@H](C(C=[N+]=[N-])=O)CC2=CC=C(OC(C)(C)C)C=C2)=O)OCC3=CC=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 542.64 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1. Shaw, E., Mohanty, S., Colic, A., et al. The affinity-labelling of cathepsin S with peptidyl diazomethyl ketones. Comparison with the inhibition of cathepsin L and calpain. FEBS Lett. 334(3), 340-342 (1993).
2. Kirschke, H., Wikstrom, P., and Shaw, E. Active center differences between cathepsins L and B: The S1 binding region. FEBS Lett. 228(1), 128-130 (1988).
3. Nkemngu, N.J., Grande, R., Hansell, E., et al. Improved trypanocidal activities of cathepsin L inhibitors. Int. J. Antimicrob. Agents 22(2), 155-159 (2003).
