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MedKoo CAT#: 585191

CAS#: 1824-52-8

Description: Bemetizide is a diuretic agent.

Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-09-27. Prices are subject to change without notice.

Bemetizide is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 585191
Name: Bemetizide
CAS#: 1824-52-8
Chemical Formula: C15H16ClN3O4S2
Exact Mass: 401.0271
Molecular Weight: 401.88
Elemental Analysis: C, 44.83; H, 4.01; Cl, 8.82; N, 10.46; O, 15.92; S, 15.96

Synonym: SU 7078; SU7078; SU-7078; DIU 60; Pertensosanol; Bemetizide

IUPAC/Chemical Name: 6-Chloro-3,4-dihydro-3-(alpha-methylbenzyl)-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide


InChi Code: InChI=1S/C15H16ClN3O4S2/c1-9(10-5-3-2-4-6-10)15-18-12-7-11(16)13(24(17,20)21)8-14(12)25(22,23)19-15/h2-9,15,18-19H,1H3,(H2,17,20,21)

SMILES Code: O=S(C1=C(Cl)C=C(C2=C1)NC(C(C)C3=CC=CC=C3)NS2(=O)=O)(N)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Düsing R, Nicolas V, Glatte B, Glänzer K, Kipnowski J, Kramer HJ. Interaction of bemetizide and indomethacin in the kidney. Br J Clin Pharmacol. 1983 Oct;16(4):377-83. PubMed PMID: 6578835; PubMed Central PMCID: PMC1428027.

2: Mühlberg W, Mutschler E, Hofner A, Spahn-Langguth H, Arnold O. The influence of age on the pharmacokinetics and pharmacodynamics of bemetizide and triamterene: a single and multiple dose study. Arch Gerontol Geriatr. 2001 Jun;32(3):265-73. PubMed PMID: 11395172.

3: Knauf H, Cawello W, Schmidt G, Mutschler E. The saluretic effect of the thiazide diuretic bemetizide in relation to the glomerular filtration rate. Eur J Clin Pharmacol. 1994;46(1):9-13. PubMed PMID: 8005195.

4: Hornung R, Keiso H, Raftery EB, Whittington JR. Placebo-controlled trial of a combination of bemetizide and triamterene ('Hypertane') in mild or moderate hypertension. Curr Med Res Opin. 1983;8(6):425-33. PubMed PMID: 6342957.

5: Selvaag E, Anholt H, Moan J, Thune P. Inhibiting effects of antioxidants on drug-induced phototoxicity in cell cultures. Investigations with sulphonamide-derived oral antidiabetics and diuretics. J Photochem Photobiol B. 1997 Mar;38(1):88-93. PubMed PMID: 9134756.


7: Neumann D, Schmidt G. [Diuretic and saluretic effects of bemetizide and triamterene compared to those of their combination (author's transl)]. Arzneimittelforschung. 1977;27(3):559-62. German. PubMed PMID: 577422.

8: Wray R, Benton KG, Whitehill D, Wright B, Weener W, Whittington JR. Comparative clinical trial of bemetizide/triamterene and cyclopenthiazide/potassium chloride combinations in patients with mild to moderate hypertension. Curr Med Res Opin. 1983;8(9):665-74. PubMed PMID: 6365467.

9: Lederle RM, Klaus D. [Treatment of hypertension with bupranolol, bemetizide and triamterene]. Dtsch Med Wochenschr. 1982 Oct 22;107(42):1587-91. German. PubMed PMID: 7128471.

10: Piper C, Cawello W, Bonn R, Weber E. [Pharmacodynamics and pharmacokinetics of bemetizid in comparison with hydrochlorothiazide. A controlled human pharmacologic study of acute effects]. Arzneimittelforschung. 1983;33(7):988-96. German. PubMed PMID: 6684935.

11: Brodie RR, Chasseaud LF, Darragh A, Taylor T, Walmsley LM. Bioavailability of bemetizide and triamterene from a combination formulation. Biopharm Drug Dispos. 1982 Oct-Dec;3(4):361-70. PubMed PMID: 7159690.

12: Felix W, Manz M. [Effect of triamterene and bemetizide on transcapillary water metabolism]. Med Welt. 1975 May 23;26(21):1043-50. German. PubMed PMID: 1143071.

13: Selvaag E, Anholt H, Moan J, Thune P. Phototoxicity due to sulphonamide derived oral antidiabetics and diuretics: investigations in a cell culture model. Photodermatol Photoimmunol Photomed. 1996 Feb;12(1):1-6. PubMed PMID: 8884891.

14: Brodie RR, Chasseaud LF, Taylor T. Determination of the thiazide diuretic bemetizide in the plasma and urine of humans by high-performance liquid chromatography. J Chromatogr. 1978 Jul 1;146(1):152-6. PubMed PMID: 670351.

15: Schäfer GE, Werner E. [The effect of bemetizide-triamterene on the serum and whole body potassium in hypertensive patients (author's transl)]. MMW Munch Med Wochenschr. 1978 Nov 10;120(45):1505-7. German. PubMed PMID: 101820.

16: Gasser RW, Brandstetter G, Skrabal F. [Treatment of hypertension with a drug combination, consisting of bemetizide, triamterene, dihydralazine and bupranolol (author's transl)]. Wien Klin Wochenschr. 1982 Jan 8;94(1):25-8. German. PubMed PMID: 7080491.

17: Selvaag E, Thune P. Phototoxicity to sulphonamide-derived oral antidiabetics and diuretics: investigations in hairless mice. Photodermatol Photoimmunol Photomed. 1997 Feb-Apr;13(1-2):4-8. PubMed PMID: 9361121.

18: Schrey A, Schmidt G, Ziegler WJ. [Experiences with a combination of bemetizide and triamterene in the ambulatory treatment of hypertension. Report of a multicentric study]. Med Welt. 1978 Dec 8;29(49):1936-43. German. PubMed PMID: 732567.

19: Neumann D, Haase W. [Effect of the diuretics bemetizide and triamterene on renal excretion of potassium and sodium. Animal experiments]. Med Welt. 1977 Oct 7;28(40):1621-3. German. PubMed PMID: 927120.

20: Selvaag E. Inhibition of thiazide photohemolysis in vitro by antioxidants and a nitrogen atmosphere. Photodermatol Photoimmunol Photomed. 1996 Oct;12(5):211-5. PubMed PMID: 9112280.