A 784168
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558771

CAS#: 824982-41-4

Description: A-784168 is a potent and selective antagonist of Vanilloid receptor type 1 (TRPV1).


Chemical Structure

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A 784168
CAS# 824982-41-4

Theoretical Analysis

MedKoo Cat#: 558771
Name: A 784168
CAS#: 824982-41-4
Chemical Formula: C19H15F6N3O3S
Exact Mass: 479.07
Molecular Weight: 479.4
Elemental Analysis: C, 47.60; H, 3.15; F, 23.78; N, 8.77; O, 10.01; S, 6.69

Price and Availability

Size Price Availability Quantity
10.0mg USD 395.0 2 Weeks
50.0mg USD 1315.0 2 Weeks
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Synonym: A 784168, A784168, A-784168

IUPAC/Chemical Name: 3,6-Dihydro-3'-(trifluoromethyl)-N-[4-[(trifluoromethyl)sulfonyl]phenyl]-[1(2H),2'-bipyridine]-4-carboxamide

InChi Key: SDUAWRFBHRAFBM-UHFFFAOYSA-N

InChi Code: 1S/C19H15F6N3O3S/c20-18(21,22)15-2-1-9-26-16(15)28-10-7-12(8-11-28)17(29)27-13-3-5-14(6-4-13)32(30,31)19(23,24)25/h1-7,9H,8,10-11H2,(H,27,29)

SMILES Code: FC(F)(F)C1=CC=CN=C1N2CCC(=CC2)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 479.4 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Bianchi et al (2007) [3H]-A-778317 [1-((R-5-tert-butyl-indan-1-yl)-3-isoquinolin-5-yl-urea]: a novel, stereoselective, high-affinity antagonist is a useful radioligand for the human transient receptor potential vanilloid-1 (TRPV1) receptor. J.Pharmacol.Exp.Ther. 323 285 PMID: 17660385

2. Cui et al (2006) TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists. J.Neurosci. 26 9385 PMID: 16971522

A 784168

10.0mg / USD 395.0