N6-Cyclohexyladenosine
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MedKoo CAT#: 573991

CAS#: 36396-99-3

Description: N6-Cyclohexyladenosine is an adenosine receptor agonist. It selectively binds to adenosine A1 receptors over A2 receptors. N6-Cyclohexyladenosine decreases heart rate, increases coronary flow, and induces sleep. N6-Cyclohexyladenosine also decreases locomotor activity in mice.


Chemical Structure

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N6-Cyclohexyladenosine
CAS# 36396-99-3

Theoretical Analysis

MedKoo Cat#: 573991
Name: N6-Cyclohexyladenosine
CAS#: 36396-99-3
Chemical Formula: C16H23N5O4
Exact Mass: 349.175
Molecular Weight: 349.39
Elemental Analysis: C, 55.00; H, 6.64; N, 20.04; O, 18.32

Price and Availability

Size Price Availability Quantity
25.0mg USD 230.0 2 Weeks
50.0mg USD 370.0 2 Weeks
100.0mg USD 600.0 2 Weeks
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Synonym: N6-Cyclohexyladenosine

IUPAC/Chemical Name: N-cyclohexyl-adenosine

InChi Key: SZBULDQSDUXAPJ-XNIJJKJLSA-N

InChi Code: InChI=1S/C16H23N5O4/c22-6-10-12(23)13(24)16(25-10)21-8-19-11-14(17-7-18-15(11)21)20-9-4-2-1-3-5-9/h7-10,12-13,16,22-24H,1-6H2,(H,17,18,20)/t10-,12-,13-,16-/m1/s1

SMILES Code: [H][C@]1(O[C@H](CO)[C@@H](O)[C@H]1O)N2C=NC3=C(NC4CCCCC4)N=CN=C32

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 349.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1. Hutchison, A.J., Webb, R.L., Oei, H.H., et al. CGS 21680C, an A2 selective adenosine receptor agonist with preferential hypotensive activity. J. Pharmacol. Exp. Ther. 251(1), 47-55 (1989).

2. Blanco-Centurion, C., Xu, M., Murillo-Rodriguez, E., et al. Adenosine and sleep homeostasis in the basal forebrain. J Neurosci. 26(31), 8092-8100 (2006).

3. Nikodijević, O., Daly, J.W., and Jacobson, K.A. Characterization of the locomotor depression produced by an A2-selective adenosine agonist. FEBS Lett. 261(1), 67-70 (1990).