WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558768
Description: A 1120 is a retinol-binding protein 4 (RBP4) antagonist (Ki = 8.3 nM) that can reduce serum RBP4 and retinol, and displaces transthyretin (TTR) from RBP4-TTR complexes.
MedKoo Cat#: 558768
Name: A 1120
Chemical Formula: C20H19F3N2O3
Exact Mass: 392.1348
Molecular Weight: 392.3782
Elemental Analysis: C, 61.22; H, 4.88; F, 14.53; N, 7.14; O, 12.23
Synonym: A-1120, A1120, 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
IUPAC/Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid
InChi Key: MEAQCLPMSVEOQF-UHFFFAOYSA-N
SMILES Code: O=C(NC3=C(C(O)=O)C=CC=C3)N1CCC(C2=C(C(F)(F)F)C=CC=C2)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 392.3782 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Wilkins T, Agabin E, Varghese J, Talukder A. Gallbladder Dysfunction:
Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. Prim
Care. 2017 Dec;44(4):575-597. doi: 10.1016/j.pop.2017.07.002. Epub 2017 Oct 5.
Review. PubMed PMID: 29132521.
2: Xue C, Tian Y, Zhang J, Zhao Y, Zhan J, Fang W, Zhang L. Efficacy of BIBF 1120
or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo.
Drug Des Devel Ther. 2016 Mar 15;10:1173-80. doi: 10.2147/DDDT.S96634.
eCollection 2016. PubMed PMID: 27042009; PubMed Central PMCID: PMC4801128.
3. Manolescu et al (2009) All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases Ins sensitivity in diabetic mice. J.Nutr. 140 311 PMID: 20032483
4. Motani et al (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 284 7673 PMID: 19147488