A 1120
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 558768

CAS#: 1152782-19-8

Description: A 1120 is a retinol-binding protein 4 (RBP4) antagonist (Ki = 8.3 nM) that can reduce serum RBP4 and retinol, and displaces transthyretin (TTR) from RBP4-TTR complexes.


Chemical Structure

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A 1120
CAS# 1152782-19-8

Theoretical Analysis

MedKoo Cat#: 558768
Name: A 1120
CAS#: 1152782-19-8
Chemical Formula: C20H19F3N2O3
Exact Mass: 392.1348
Molecular Weight: 392.3782
Elemental Analysis: C, 61.22; H, 4.88; F, 14.53; N, 7.14; O, 12.23

Price and Availability

Size Price Availability Quantity
10.0mg USD 450.0 2 Weeks
50.0mg USD 1450.0 2 Weeks
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Synonym: A-1120, A1120, 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

IUPAC/Chemical Name: 2-(4-(2-(Trifluoromethyl)phenyl)piperidine-1-carboxamido)benzoic acid

InChi Key: MEAQCLPMSVEOQF-UHFFFAOYSA-N

SMILES Code: O=C(NC3=C(C(O)=O)C=CC=C3)N1CCC(C2=C(C(F)(F)F)C=CC=C2)CC1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 392.3782 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Wilkins T, Agabin E, Varghese J, Talukder A. Gallbladder Dysfunction:
Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. Prim
Care. 2017 Dec;44(4):575-597. doi: 10.1016/j.pop.2017.07.002. Epub 2017 Oct 5.
Review. PubMed PMID: 29132521.

2: Xue C, Tian Y, Zhang J, Zhao Y, Zhan J, Fang W, Zhang L. Efficacy of BIBF 1120
or BIBF 1120 plus chemotherapy on nasopharyngeal carcinoma in vitro and in vivo.
Drug Des Devel Ther. 2016 Mar 15;10:1173-80. doi: 10.2147/DDDT.S96634.
eCollection 2016. PubMed PMID: 27042009; PubMed Central PMCID: PMC4801128.

3. Manolescu et al (2009) All-trans retinoic acid lowers serum retinol-binding protein 4 concentrations and increases Ins sensitivity in diabetic mice. J.Nutr. 140 311 PMID: 20032483

4. Motani et al (2009) Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo. J.Biol.Chem. 284 7673 PMID: 19147488

A 1120

10.0mg / USD 450.0