WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573985

CAS#: 2009-24-7

Description: Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro. Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita. In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively.4 It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.

Chemical Structure

CAS# 2009-24-7

Theoretical Analysis

MedKoo Cat#: 573985
Name: Xanthotoxol
CAS#: 2009-24-7
Chemical Formula: C11H6O4
Exact Mass: 202.03
Molecular Weight: 202.160
Elemental Analysis: C, 65.35; H, 2.99; O, 31.66

Price and Availability

Size Price Availability Quantity
25mg USD 230
250mg USD 345
1g USD 510
2g USD 810
5g USD 1410
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Synonym: Xanthotoxol, Xanthotol, 8-Hydroxypsoralen, NSC 401269

IUPAC/Chemical Name: 9-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one

InChi Key: OC1=C(OC=C2)C2=CC(C=C3)=C1OC3=O

InChi Code: InChI=1S/C11H6O4/c12-8-2-1-6-5-7-3-4-14-10(7)9(13)11(6)15-8/h1-5,13H


Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 202.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1. Bai, Y., Li, D., Zhou, T., et al. Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities. J. Funct. Foods 20, 453-462 (2016).

2. Li, D., and Wu, L. Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation. Exp. Ther. Med. 14(1), 874-880 (2017).

3. Caboni, P., Saba, M., Oplos, C., et al. Nematicidal activity of furanocoumarins from parsley against Meloidogyne spp. Pest. Manag. Sci. 71(8), 1099-1105 (2015).

4. Sethi, O.P., Anand, K.K., and Gulati, O.D. Evaluation of xanthotoxol for central nervous system activity. J. Ethnopharmacol. 36(3), 239-247 (1992).

5. He, W., Chen, W., Zhou, Y., et al. Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia. Cell. Mol. Neurobiol. 33(5), 715-722 (2013).