Xanthotoxol
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573985

CAS#: 2009-24-7

Description: Xanthotoxol is a coumarin and a major component in C. monnieri that has diverse biological activities. It inhibits proliferation of HeLa and HepG2 cells in vitro. Xanthotoxol increases histamine release from mast cells and decreases secretion of TNF-α, IL-4, and IL-1β from RBL-2H3 cells induced by DNP-human serum albumin (DNP-HSA). It is nematocidal against M. incognita. In vivo, xanthotoxol inhibits predatory mouse and rat killing behavior in dogs and cats when administered at doses ranging from 3 to 100 mg/kg and 5 to 20 mg/kg, respectively.4 It reduces amphetamine-induced hypermobility in mice and hamsters. Xanthotoxol (5 and 10 mg/kg) reduces brain edema, neutrophil infiltration, blood-brain barrier disruption, production of IL-1β, TNF-α, IL-8, and nitric oxide (NO), and levels of intercellular adhesion molecule-1 (ICAM-1) and E-selectin in a rat model of focal cerebral ischemia.


Price and Availability

Size
Price

25mg
USD 230
2g
USD 810
Size
Price

250mg
USD 345
5g
USD 1410
Size
Price

1g
USD 510

Xanthotoxol, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 573985
Name: Xanthotoxol
CAS#: 2009-24-7
Chemical Formula: C11H6O4
Exact Mass: 202.0266
Molecular Weight: 202.16
Elemental Analysis: C, 65.35; H, 2.99; O, 31.66


Synonym: Xanthotoxol, Xanthotol, 8-Hydroxypsoralen, NSC 401269

IUPAC/Chemical Name: 9-hydroxy-7H-furo[3,2-g][1]benzopyran-7-one

InChi Key: OC1=C(OC=C2)C2=CC(C=C3)=C1OC3=O

InChi Code: InChI=1S/C11H6O4/c12-8-2-1-6-5-7-3-4-14-10(7)9(13)11(6)15-8/h1-5,13H

SMILES Code: JWVYQQGERKEAHW-UHFFFAOYSA-N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1. Bai, Y., Li, D., Zhou, T., et al. Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities. J. Funct. Foods 20, 453-462 (2016).

2. Li, D., and Wu, L. Coumarins from the roots of Angelica dahurica cause anti-allergic inflammation. Exp. Ther. Med. 14(1), 874-880 (2017).

3. Caboni, P., Saba, M., Oplos, C., et al. Nematicidal activity of furanocoumarins from parsley against Meloidogyne spp. Pest. Manag. Sci. 71(8), 1099-1105 (2015).

4. Sethi, O.P., Anand, K.K., and Gulati, O.D. Evaluation of xanthotoxol for central nervous system activity. J. Ethnopharmacol. 36(3), 239-247 (1992).

5. He, W., Chen, W., Zhou, Y., et al. Xanthotoxol exerts neuroprotective effects via suppression of the inflammatory response in a rat model of focal cerebral ischemia. Cell. Mol. Neurobiol. 33(5), 715-722 (2013).