WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558767
Description: Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.
MedKoo Cat#: 558767
Name: A 1070722
Chemical Formula: C17H13F3N4O2
Exact Mass: 362.1
Molecular Weight: 362.31
Elemental Analysis: C, 56.36; H, 3.62; F, 15.73; N, 15.46; O, 8.83
IUPAC/Chemical Name: 1-(7-methoxyquinolin-4-yl)-3-(6-(trifluoromethyl)pyridin-2-yl)urea
InChi Key: VQPBIJGXSXEOCU-UHFFFAOYSA-N
SMILES Code: O=C(NC3=NC(C(F)(F)F)=CC=C3)NC2=CC=NC1=CC(OC)=CC=C12