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Potent glycogen synthase kinase-3 (GSK-3) inhibitor (Ki = 0.6 nM for GSK-3α and GSK-3β). Displays high selectivity (> 50-fold) for GSK-3 over a panel of other kinases tested, including CDK family members. Decreases phosphorylation of microtubule-associated protein Tau in vitro; protects rat primary cortical neurons against β amyloid and glutamate challenge. Brain penetrant.
Price and Availability
Pricing updated 2020-06-03.
Prices are subject to change without notice.
is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to email@example.com to inquire quote.
MedKoo Cat#: 558767
Name: A 1070722
Chemical Formula: C17H13F3N4O2
Exact Mass: 362.1
Molecular Weight: 362.31
Elemental Analysis: C, 56.36; H, 3.62; F, 15.73; N, 15.46; O, 8.83