CAY10594
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MedKoo CAT#: 555649

CAS#: 1130067-34-3

Description: CAY10594 is a potent phospholipase D2 inhibitor. CAY10594 ameliorates acetaminophen-induced acute liver injury by regulating the phosphorylated-GSK-3β/JNK axis.


Price and Availability

Size
Price

100mg
USD 550
1g
USD 2950
Size
Price

200mg
USD 950
2g
USD 4650
Size
Price

500mg
USD 1850

CAY10594, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555649
Name: CAY10594
CAS#: 1130067-34-3
Chemical Formula: C26H28N4O2
Exact Mass: 428.2212
Molecular Weight: 428.536
Elemental Analysis: C, 72.87; H, 6.59; N, 13.07; O, 7.47


Synonym: CAY10594; CAY-10594; CAY 10594;

IUPAC/Chemical Name: N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-naphthalenecarboxamide

InChi Key: FAIFAFUXFFWVNQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C26H28N4O2/c31-24(22-11-10-20-6-4-5-7-21(20)18-22)27-14-17-29-15-12-26(13-16-29)25(32)28-19-30(26)23-8-2-1-3-9-23/h1-11,18H,12-17,19H2,(H,27,31)(H,28,32)

SMILES Code: O=C(C1=CC=C2C=CC=CC2=C1)NCCN(CC3)CCC3(N(C4=CC=CC=C4)CN5)C5=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Lee SK, Bae GH, Kim YS, Kim HS, Lee M, Ghim J, Zabel BA, Ryu SH, Bae YS. A
phospholipase D2 inhibitor, CAY10594, ameliorates acetaminophen-induced acute
liver injury by regulating the phosphorylated-GSK-3β/JNK axis. Sci Rep. 2019 May
10;9(1):7242. doi: 10.1038/s41598-019-43673-x. PubMed PMID: 31076618; PubMed
Central PMCID: PMC6510900.

2: Zhou G, Yu L, Yang W, Wu W, Fang L, Liu Z. Blockade of PLD2 Ameliorates
Intestinal Mucosal Inflammation of Inflammatory Bowel Disease. Mediators Inflamm.
2016;2016:2543070. Epub 2016 Sep 18. PubMed PMID: 27721573; PubMed Central PMCID:
PMC5046040.

3: Choudhary V, Olala LO, Qin H, Helwa I, Pan ZQ, Tsai YY, Frohman MA,
Kaddour-Djebbar I, Bollag WB. Aquaporin-3 re-expression induces differentiation
in a phospholipase D2-dependent manner in aquaporin-3-knockout mouse
keratinocytes. J Invest Dermatol. 2015 Feb;135(2):499-507. doi:
10.1038/jid.2014.412. Epub 2014 Sep 18. PubMed PMID: 25233074.

4: Hong-Brown LQ, Brown CR, Navaratnarajah M, Lang CH. Activation of
AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes.
Alcohol Clin Exp Res. 2013 Nov;37(11):1849-61. doi: 10.1111/acer.12174. Epub 2013
Jul 29. PubMed PMID: 23895284; PubMed Central PMCID: PMC3812405.

5: Pupovac A, Stokes L, Sluyter R. CAY10593 inhibits the human P2X7 receptor
independently of phospholipase D1 stimulation. Purinergic Signal. 2013
Dec;9(4):609-19. doi: 10.1007/s11302-013-9371-6. Epub 2013 Jun 21. PubMed PMID:
23793974; PubMed Central PMCID: PMC3889394.

6: Roy A, Derakhshan F, Wilson RJ. Stress peptide PACAP engages multiple
signaling pathways within the carotid body to initiate excitatory responses in
respiratory and sympathetic chemosensory afferents. Am J Physiol Regul Integr
Comp Physiol. 2013 Jun 15;304(12):R1070-84. doi: 10.1152/ajpregu.00465.2012. Epub
2013 Apr 17. PubMed PMID: 23594614.