WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555645
Description: GSK2894631A is a hematopoietic PGD synthase (HPGDS) inhibitor.
MedKoo Cat#: 555645
Chemical Formula: C20H24F2N2O3
Exact Mass: 378.1755
Molecular Weight: 378.4198
Elemental Analysis: C, 63.48; H, 6.39; F, 10.04; N, 7.40; O, 12.68
Synonym: GSK2894631A; GSK-2894631A; GSK 2894631A; GSK2894631; GSK-2894631; GSK 2894631;
IUPAC/Chemical Name: 7-(Difluoromethoxy)-N-[trans-4-(1-hydroxy-1-methylethyl)cyclohexyl]-3-quinolinecarboxamide
InChi Key: YRWMWDLEUYLURJ-SHTZXODSSA-N
InChi Code: InChI=1S/C20H24F2N2O3/c1-20(2,26)14-4-6-15(7-5-14)24-18(25)13-9-12-3-8-16(27-19(21)22)10-17(12)23-11-13/h3,8-11,14-15,19,26H,4-7H2,1-2H3,(H,24,25)/t14-,15-
SMILES Code: O=C(C1=CC2=CC=C(OC(F)F)C=C2N=C1)N[C@H]3CC[C@H](C(C)(O)C)CC3
Injured tendons heal through the formation of a fibrovascular scar that has inferior mechanical properties compared to native tendon tissue. Reducing inflammation that occurs as a result of the injury could limit scar formation and improve functional recovery of tendons. Prostaglandin D2 (PGD2 ) plays an important role in promoting inflammation in some injury responses and chronic disease processes, and the inhibition of PGD2 has improved healing and reduced disease burden in animal models and early clinical trials. Based on these findings, we sought to determine the role of PGD2 signaling in the healing of injured tendon tissue.
Sarver DC, Sugg KB, Talarek JR, et al. Prostaglandin D2 signaling is not involved in the recovery of rat hind limb tendons from injury. Physiol Rep. 2019;7(22):e14289. doi:10.14814/phy2.14289