ZK824859
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555643

CAS#: 2254001-81-3 (free acid)

Description: ZK824859 is a potent uPA inhibitor as a potential treatment for multiple sclerosis. ZK824859 showed activity to lower clinical scores when dosed in either acute or chronic mouse EAE mode.


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 1950
5g
USD 7950
Size
Price

100mg
USD 750
1g
USD 2950
Size
Price

200mg
USD 1250
2g
USD 5450

ZK824859, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555643
Name: ZK824859
CAS#: 2254001-81-3 (free acid)
Chemical Formula: C23H22F2N2O4
Exact Mass: 428.1548
Molecular Weight: 428.4358
Elemental Analysis: C, 64.48; H, 5.18; F, 8.87; N, 6.54; O, 14.94


Related CAS #: 2254001-81-3 (free acid)    

Synonym: ZK824859; ZK-824859; ZK 824859; CAS#2254001-81-3

IUPAC/Chemical Name: (R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid

InChi Key: CVNXUNVHFJANHX-HXUWFJFHSA-N

InChi Code: InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1

SMILES Code: CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan
K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C,
Sukovich D, Whitlow M, Chen D, Buckman BO. Discovery of selective urokinase
plasminogen activator (uPA) inhibitors as a potential treatment for multiple
sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi:
10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5. PubMed PMID: 30201291.