ZK824859
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MedKoo CAT#: 555643

CAS#: 2254001-81-3 (free acid)

Description: ZK824859 is a potent uPA inhibitor as a potential treatment for multiple sclerosis. ZK824859 showed activity to lower clinical scores when dosed in either acute or chronic mouse EAE mode.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 450 2 Weeks
100mg USD 750 2 Weeks
200mg USD 1250 2 Weeks
500mg USD 1950 2 Weeks
1g USD 2950 2 Weeks
2g USD 5450 2 Weeks
5g USD 7950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-06-05. Prices are subject to change without notice.

ZK824859, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555643
Name: ZK824859
CAS#: 2254001-81-3 (free acid)
Chemical Formula: C23H22F2N2O4
Exact Mass: 428.1548
Molecular Weight: 428.4358
Elemental Analysis: C, 64.48; H, 5.18; F, 8.87; N, 6.54; O, 14.94


Related CAS #: 2254001-81-3 (free acid)    

Synonym: ZK824859; ZK-824859; ZK 824859; CAS#2254001-81-3

IUPAC/Chemical Name: (R)-2-((6-((3'-(aminomethyl)-5-methyl-[1,1'-biphenyl]-3-yl)oxy)-3,5-difluoropyridin-2-yl)oxy)butanoic acid

InChi Key: CVNXUNVHFJANHX-HXUWFJFHSA-N

InChi Code: InChI=1S/C23H22F2N2O4/c1-3-20(23(28)29)31-22-19(25)11-18(24)21(27-22)30-17-8-13(2)7-16(10-17)15-6-4-5-14(9-15)12-26/h4-11,20H,3,12,26H2,1-2H3,(H,28,29)/t20-/m1/s1

SMILES Code: CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Islam I, Yuan S, West CW, Adler M, Bothe U, Bryant J, Chang Z, Chu K, Emayan
K, Gualtieri G, Ho E, Light D, Mallari C, Morser J, Phillips G, Schaefer C,
Sukovich D, Whitlow M, Chen D, Buckman BO. Discovery of selective urokinase
plasminogen activator (uPA) inhibitors as a potential treatment for multiple
sclerosis. Bioorg Med Chem Lett. 2018 Nov 1;28(20):3372-3375. doi:
10.1016/j.bmcl.2018.09.001. Epub 2018 Sep 5. PubMed PMID: 30201291.