WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555632
Description: DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases, including Aurora-A, FLT3, CSF1R, MET, etc. DBPR114 exhibited favorable PK profiles: a long half-life (t1/2 = 23.5 h), moderate clearance and high volume of distribution. Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11, MIA PaCa-2, Hep3B, MKN45, Colo205, and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.
MedKoo Cat#: 555632
Chemical Formula: C25H28ClN7O2S
Exact Mass: 525.1714
Molecular Weight: 526.056
Elemental Analysis: C, 57.08; H, 5.37; Cl, 6.74; N, 18.64; O, 6.08; S, 6.09
Synonym: DBPR114; DBPR=114; DBPR 114;
IUPAC/Chemical Name: 1-(3-chlorophenyl)-3-(5-(2-((7-(3-(dimethylamino)propoxy)quinazolin-4-yl)amino)ethyl)thiazol-2-yl)urea
InChi Key: MMVLETOTGHDVPQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H28ClN7O2S/c1-33(2)11-4-12-35-19-7-8-21-22(14-19)29-16-30-23(21)27-10-9-20-15-28-25(36-20)32-24(34)31-18-6-3-5-17(26)13-18/h3,5-8,13-16H,4,9-12H2,1-2H3,(H,27,29,30)(H2,28,31,32,34)
SMILES Code: O=C(NC1=NC=C(CCNC2=C3C=CC(OCCCN(C)C)=CC3=NC=N2)S1)NC4=CC=CC(Cl)=C4