DBPR114
new
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555632

CAS#: Unknown

Description: DBPR114 is a potent multi-kinase inhibitor with potent activities against more than 57 oncogenic kinases, including Aurora-A, FLT3, CSF1R, MET, etc. DBPR114 exhibited favorable PK profiles: a long half-life (t1/2 = 23.5 h), moderate clearance and high volume of distribution. Also DBPR114 can effectively inhibit the growth of human acute myeloid leukemia MOLM-13 and MV4-11, MIA PaCa-2, Hep3B, MKN45, Colo205, and NTUB1 solid tumor xenografts in vivo without causing significant body weight loss.


Price and Availability

Size
Price

500mg
USD 2950
Size
Price

1g
USD 4650
Size
Price

2g
USD 7650

DBPR114, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 555632
Name: DBPR114
CAS#: Unknown
Chemical Formula: C25H28ClN7O2S
Exact Mass: 525.1714
Molecular Weight: 526.056
Elemental Analysis: C, 57.08; H, 5.37; Cl, 6.74; N, 18.64; O, 6.08; S, 6.09


Synonym: DBPR114; DBPR=114; DBPR 114;

IUPAC/Chemical Name: 1-(3-chlorophenyl)-3-(5-(2-((7-(3-(dimethylamino)propoxy)quinazolin-4-yl)amino)ethyl)thiazol-2-yl)urea

InChi Key: MMVLETOTGHDVPQ-UHFFFAOYSA-N

InChi Code: InChI=1S/C25H28ClN7O2S/c1-33(2)11-4-12-35-19-7-8-21-22(14-19)29-16-30-23(21)27-10-9-20-15-28-25(36-20)32-24(34)31-18-6-3-5-17(26)13-18/h3,5-8,13-16H,4,9-12H2,1-2H3,(H,27,29,30)(H2,28,31,32,34)

SMILES Code: O=C(NC1=NC=C(CCNC2=C3C=CC(OCCCN(C)C)=CC3=NC=N2)S1)NC4=CC=CC(Cl)=C4


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01