SIS-17
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555620

CAS#: 2374313-54-7

Description: SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.


Price and Availability

Size
Price

10mg
USD 150
100mg
USD 750
1g
USD 2950
Size
Price

25mg
USD 250
200mg
USD 1250
2g
USD 4650
Size
Price

50mg
USD 450
500mg
USD 1950
5g
USD 7650

SIS-17, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555620
Name: SIS-17
CAS#: 2374313-54-7
Chemical Formula: C21H38N2OS
Exact Mass: 366.2705
Molecular Weight: 366.608
Elemental Analysis: C, 68.80; H, 10.45; N, 7.64; O, 4.36; S, 8.75


Synonym: SIS-17; SIS 17; SIS17;

IUPAC/Chemical Name: N'-hexadecylthiophene-2-carbohydrazide

InChi Key: HSHXDCVZWHOWCS-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)

SMILES Code: O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


Additional Information

Mammalian histone deacetylases (HDACs) are a class of enzymes that play important roles in biological pathways. Existing HDAC inhibitors target multiple HDACs without much selectivity. Inhibitors that target one particular HDAC will be useful for investigating the biological functions of HDACs and for developing better therapeutics.


References

1: Son SI, Cao J, Zhu CL, Miller SP, Lin H. Activity-Guided Design of
HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14(7):1393-1397. doi:
10.1021/acschembio.9b00292. Epub 2019 Jul 2. PubMed PMID: 31264832.