WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573921

CAS#: 129580-58-1

Description: JM-244amine is a Pt(IV) dicarboxylates that may be useful in the study of carcinoma cell lines. JM-244 slows S-phase transit and blocks G2. Studies show cells die either through apoptosis (largely during S-phase) or by failing to overcome the G2 block (some days after treatment). In G2, the cells either divided or became enlarged and died.

Chemical Structure

CAS# 129580-58-1

Theoretical Analysis

MedKoo Cat#: 573921
Name: JM-244
CAS#: 129580-58-1
Chemical Formula: C17H22Cl2N2O4Pt
Exact Mass: 583.0604
Molecular Weight: 584.36
Elemental Analysis: C, 34.94; H, 3.79; Cl, 12.13; N, 4.79; O, 10.95; Pt, 33.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: JM 244, JM-244, JM244

IUPAC/Chemical Name: Platinum, amminebis(benzoato-O)dichloro(1-propanamine)-, (OC-6-43)-


InChi Code: 1S/2C7H6O2.C3H9N.2ClH.H3N.Pt/c2*8-7(9)6-4-2-1-3-5-6;1-2-3-4;;;;/h2*1-5H,(H,8,9);2-4H2,1H3;2*1H;1H3;/q;;;;;;+4/p-4

SMILES Code: [Pt+4].NCCC.N.[ClH-].[ClH-].c1(ccccc1)C([O-])=O.c1(ccccc1)C([O-])=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 584.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Ormerod MG, Orr RM, O'Neill CF, Chwalinski T, Titley JC, Kelland LR, Harrap KR. The cytotoxic action of four ammine/amine platinum(IV) dicarboxylates: a flow cytometric study. Br J Cancer. 1996 Dec;74(12):1935-43. PubMed PMID: 8980393; PubMed Central PMCID: PMC2074815.

2: Orr RM, O'Neill CF, Nicolson MC, Barnard CF, Murrer BA, Giandomenico CM, Vollano JF, Harrap KR. Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin. Br J Cancer. 1994 Sep;70(3):415-20. PubMed PMID: 8080724; PubMed Central PMCID: PMC2033379.

3: Kelland LR, Mistry P, Abel G, Loh SY, O'Neill CF, Murrer BA, Harrap KR. Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates. Cancer Res. 1992 Jul 15;52(14):3857-64. PubMed PMID: 1617660.

4: Kelland LR, Murrer BA, Abel G, Giandomenico CM, Mistry P, Harrap KR. Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res. 1992 Feb 15;52(4):822-8. PubMed PMID: 1737343.