WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573921
Description: JM-244amine is a Pt(IV) dicarboxylates that may be useful in the study of carcinoma cell lines. JM-244 slows S-phase transit and blocks G2. Studies show cells die either through apoptosis (largely during S-phase) or by failing to overcome the G2 block (some days after treatment). In G2, the cells either divided or became enlarged and died.
MedKoo Cat#: 573921
Chemical Formula: C17H22Cl2N2O4Pt
Exact Mass: 583.0604
Molecular Weight: 584.36
Elemental Analysis: C, 34.94; H, 3.79; Cl, 12.13; N, 4.79; O, 10.95; Pt, 33.38
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Synonym: JM 244, JM-244, JM244
IUPAC/Chemical Name: Platinum, amminebis(benzoato-O)dichloro(1-propanamine)-, (OC-6-43)-
InChi Key: CEIAKSIEJLYWAV-UHFFFAOYSA-J
InChi Code: 1S/2C7H6O2.C3H9N.2ClH.H3N.Pt/c2*8-7(9)6-4-2-1-3-5-6;1-2-3-4;;;;/h2*1-5H,(H,8,9);2-4H2,1H3;2*1H;1H3;/q;;;;;;+4/p-4
SMILES Code: [Pt+4].NCCC.N.[ClH-].[ClH-].c1(ccccc1)C([O-])=O.c1(ccccc1)C([O-])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 584.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Ormerod MG, Orr RM, O'Neill CF, Chwalinski T, Titley JC, Kelland LR, Harrap KR. The cytotoxic action of four ammine/amine platinum(IV) dicarboxylates: a flow cytometric study. Br J Cancer. 1996 Dec;74(12):1935-43. PubMed PMID: 8980393; PubMed Central PMCID: PMC2074815.
2: Orr RM, O'Neill CF, Nicolson MC, Barnard CF, Murrer BA, Giandomenico CM, Vollano JF, Harrap KR. Evaluation of novel ammine/amine platinum (IV) dicarboxylates in L1210 murine leukaemia cells sensitive and resistant to cisplatin, tetraplatin or carboplatin. Br J Cancer. 1994 Sep;70(3):415-20. PubMed PMID: 8080724; PubMed Central PMCID: PMC2033379.
3: Kelland LR, Mistry P, Abel G, Loh SY, O'Neill CF, Murrer BA, Harrap KR. Mechanism-related circumvention of acquired cis-diamminedichloroplatinum(II) resistance using two pairs of human ovarian carcinoma cell lines by ammine/amine platinum(IV) dicarboxylates. Cancer Res. 1992 Jul 15;52(14):3857-64. PubMed PMID: 1617660.
4: Kelland LR, Murrer BA, Abel G, Giandomenico CM, Mistry P, Harrap KR. Ammine/amine platinum(IV) dicarboxylates: a novel class of platinum complex exhibiting selective cytotoxicity to intrinsically cisplatin-resistant human ovarian carcinoma cell lines. Cancer Res. 1992 Feb 15;52(4):822-8. PubMed PMID: 1737343.