RP-54745
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555619

CAS#: 135330-08-4

Description: RP-54745 is an Inhibitor of macrophage stimulation and interleukin-1 production. RP 54745 might influence certain cells and cytokines implicated in the regulation of the immune system, the disfunctioning of which can lead to inflammatory disorders or autoimmune pathologies. RP-54745 is a very attractive antirheumatic compound and a potentially effective treatment in pathologies where IL-1 production is exacerbated.

Chemical Structure

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RP-54745
CAS# 135330-08-4
Instruction

Theoretical Analysis

MedKoo Cat#: 555619
Name: RP-54745
CAS#: 135330-08-4
Chemical Formula: C13H12ClNOS2
Exact Mass: 297.00
Molecular Weight: 297.815
Elemental Analysis: C, 52.43; H, 4.06; Cl, 11.90; N, 4.70; O, 5.37; S, 21.53

Price and Availability

Size Price Availability Quantity
1g USD 3250
2g USD 5450
5g USD 7650
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Synonym: RP-54745; RP 54745; RP54745;

IUPAC/Chemical Name: 4-Chloro-5-(3,4-dihydro-1-methyl-2(1H)-isoquinolinyl)-3H-1,2-dithiol-3-one

InChi Key: BEJJGVDFQORITE-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H12ClNOS2/c1-8-10-5-3-2-4-9(10)6-7-15(8)12-11(14)13(16)18-17-12/h2-5,8H,6-7H2,1H3

SMILES Code: O=C1SSC(N2C(C)C3=C(C=CC=C3)CC2)=C1Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 297.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Folliard F, Bousseau A, Terlain B. RP 54745, a potential antirheumatic
compound. II. In vivo properties in different animal models. Agents Actions. 1992
May;36(1-2):127-35. PubMed PMID: 1414681.


2: Folliard F, Bousseau A, Terlain B. RP 54745, a potential antirheumatic
compound. I. Inhibitor of macrophage stimulation and interleukin-1 production.
Agents Actions. 1992 May;36(1-2):119-26. PubMed PMID: 1414680.