WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 585108
Description: K252d is an indolocarbazole alkaloid found in Nocardiopsis. It is a PKC inhibitor that inhibits PKC isolated from rat brain, as well as, calcium- and calmodulin-dependent phosphodiesterase isolated from bovine heart.
MedKoo Cat#: 585108
Chemical Formula: C26H23N3O5
Exact Mass: 457.1638
Molecular Weight: 457.486
Elemental Analysis: C, 68.26; H, 5.07; N, 9.19; O, 17.49
IUPAC/Chemical Name: 13-(6-deoxy-α-L-mannopyranosyl)-6,7,12,13-tetrahydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazol-5-one
InChi Key: FYQXRIMLEOPQQP-DDWDLLSFSA-N
InChi Code: InChI=1S/C26H23N3O5/c1-11-22(30)23(31)24(32)26(34-11)29-16-9-5-3-7-13(16)18-19-14(10-27-25(19)33)17-12-6-2-4-8-15(12)28-20(17)21(18)29/h2-9,11,22-24,26,28,30-32H,10H2,1H3,(H,27,33)/t11-,22-,23+,24+,26+/m0/s1
SMILES Code: O=C1NCC2=C1C3=C(C4=C2C5=C(N4)C=CC=C5)N([C@H]6[C@@H]([C@@H]([C@H]([C@H](C)O6)O)O)O)C7=C3C=CC=C7
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 457.486 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1. Nakanishi, S., Matsuda, Y., Iwahashi, K., et al. K-252b, c and d, potent inhibitors of protein kinase C from microbial origin. J. Antibiot. (Tokyo) 39(8), 1066-1071 (1986).