NED3238 (HCl)
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471030

CAS#: Unknown

Description: NED3238 is new highly potent inhibitor of arginase I and II with IC50 values of 1.3 and 8.1 nM, respectively.


Price and Availability

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NED3238 (HCl), is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 471030
Name: NED3238 (HCl)
CAS#: Unknown
Chemical Formula: C17H30BCl2N3O4
Exact Mass:
Molecular Weight: 422.154
Elemental Analysis: C, 48.37; H, 7.16; B, 2.56; Cl, 16.79; N, 9.95; O, 15.16


Synonym: NED3238, NED 3238, NED-3238

IUPAC/Chemical Name: (3R,4S)-3-amino-1-((S)-2-amino-3-phenylpropyl)-4-(3-boronopropyl)pyrrolidine-3-carboxylic acid dihydrochloride

InChi Key: YLRFCKXLPZIAMP-DQZPFBHVSA-N

InChi Code: InChI=1S/C17H28BN3O4.2ClH/c19-15(9-13-5-2-1-3-6-13)11-21-10-14(7-4-8-18(24)25)17(20,12-21)16(22)23;;/h1-3,5-6,14-15,24-25H,4,7-12,19-20H2,(H,22,23);2*1H/t14-,15-,17-;;/m0../s1

SMILES Code: O=C([C@]1(N)CN(C[C@@H](N)CC2=CC=CC=C2)C[C@@H]1CCCB(O)O)O.[H]Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1. Van Zandt MC, et al. Discovery of N-Substituted 3-Amino-4-(3-boronopropyl)pyrrolidine-3-carboxylic Acids as Highly Potent Third-Generation Inhibitors of Human Arginase I and II. J Med Chem. 2019 Aug 23.