WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555608
CAS#: 1632140-61-4 (free base)
Description: JHU-58 is a novel dipeptide MrgC agonist. JHU-58 inhibited both mechanical and heat hypersensitivity in rats after an L5 spinal nerve ligation (SNL). JHU58 attenuated the evoked excitatory postsynaptic currents in substantia gelatinosa (SG) neurons in wild-type mice, but not in Mrg knockout mice, after peripheral nerve injury.
MedKoo Cat#: 555608
CAS#: 1632140-61-4 (free base)
Chemical Formula: C19H24N6O2
Exact Mass: 368.1961
Molecular Weight: 368.441
Elemental Analysis: C, 61.94; H, 6.57; N, 22.81; O, 8.68
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Related CAS #: 1632140-61-4 (free base) 1632140-59-0 (SS isomer) 1632140-62 (TFA)
Synonym: JHU-58; JHU 58; JHU58;
IUPAC/Chemical Name: (R)-2-amino-N-((S)-1-amino-1-oxo-3-phenylpropan-2-yl)-3-(4-guanidinophenyl)propanamide
InChi Key: JGVSHHWPQVGYRT-CVEARBPZSA-N
InChi Code: InChI=1S/C19H24N6O2/c20-15(10-13-6-8-14(9-7-13)24-19(22)23)18(27)25-16(17(21)26)11-12-4-2-1-3-5-12/h1-9,15-16H,10-11,20H2,(H2,21,26)(H,25,27)(H4,22,23,24)/t15-,16+/m1/s1
SMILES Code: N=C(N)NC1=CC=C(C[C@@H](N)C(N[C@H](C(N)=O)CC2=CC=CC=C2)=O)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 368.441 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Li Z, He SQ, Tseng PY, Xu Q, Tiwari V, Yang F, Shu B, Zhang T, Tang Z, Raja
SN, Wang Y, Dong X, Guan Y. The inhibition of high-voltage-activated calcium
current by activation of MrgC11 involves phospholipase C-dependent mechanisms.
Neuroscience. 2015 Aug 6;300:393-403. doi: 10.1016/j.neuroscience.2015.05.043.
Epub 2015 May 27. PubMed PMID: 26022362; PubMed Central PMCID: PMC4485588.
2: Li Z, He SQ, Xu Q, Yang F, Tiwari V, Liu Q, Tang Z, Han L, Chu YX, Wang Y, Hin
N, Tsukamoto T, Slusher B, Guan X, Wei F, Raja SN, Dong X, Guan Y. Activation of
MrgC receptor inhibits N-type calcium channels in small-diameter primary sensory
neurons in mice. Pain. 2014 Aug;155(8):1613-21. doi: 10.1016/j.pain.2014.05.008.
Epub 2014 May 9. PubMed PMID: 24813294; PubMed Central PMCID: PMC4104261.
3: He SQ, Li Z, Chu YX, Han L, Xu Q, Li M, Yang F, Liu Q, Tang Z, Wang Y, Hin N,
Tsukamoto T, Slusher B, Tiwari V, Shechter R, Wei F, Raja SN, Dong X, Guan Y.
MrgC agonism at central terminals of primary sensory neurons inhibits neuropathic
pain. Pain. 2014 Mar;155(3):534-44. doi: 10.1016/j.pain.2013.12.008. Epub 2013
Dec 11. PubMed PMID: 24333779; PubMed Central PMCID: PMC3945061.