BAM8-22
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MedKoo CAT#: 555607

CAS#: 412961-36-5

Description: BAM8-22 is a Endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM); first isolated from bovine adrenal medulla.


Price and Availability

Size Price Shipping out time Quantity
1mg USD 650 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-29. Prices are subject to change without notice.

BAM8-22, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555607
Name: BAM8-22
CAS#: 412961-36-5
Chemical Formula: C91H127N25O23S
Exact Mass: 1969.9257
Molecular Weight: 1971.229
Elemental Analysis: C, 55.45; H, 6.49; N, 17.76; O, 18.67; S, 1.63


Synonym: BAM8-22; BAM 8-22; BAM-8-22; BAM822; BAM 822; BAM-822; BAM(8-22);

IUPAC/Chemical Name: H-Val-Gly-Arg-Pro-Glu-Trp-Trp-Met-Asp-Tyr-Gln-Lys-Arg-Tyr-Gly-OH

InChi Key: GOEYECACIBFJGZ-NPAGUKBMSA-N

InChi Code: InChI=1S/C91H127N25O23S/c1-48(2)76(94)88(138)103-46-72(120)105-64(19-11-36-100-91(97)98)89(139)116-37-12-20-70(116)87(137)110-62(30-32-73(121)122)81(131)113-68(42-52-45-102-58-16-7-5-14-56(52)58)85(135)114-67(41-51-44-101-57-15-6-4-13-55(51)57)84(134)109-63(33-38-140-3)82(132)115-69(43-74(123)124)86(136)112-66(40-50-23-27-54(118)28-24-50)83(133)108-61(29-31-71(93)119)80(130)106-59(17-8-9-34-92)78(128)107-60(18-10-35-99-90(95)96)79(129)111-65(77(127)104-47-75(125)126)39-49-21-25-53(117)26-22-49/h4-7,13-16,21-28,44-45,48,59-70,76,101-102,117-118H,8-12,17-20,29-43,46-47,92,94H2,1-3H3,(H2,93,119)(H,103,138)(H,104,127)(H,105,120)(H,106,130)(H,107,128)(H,108,133)(H,109,134)(H,110,137)(H,111,129)(H,112,136)(H,113,131)(H,114,135)(H,115,132)(H,121,122)(H,123,124)(H,125,126)(H4,95,96,99)(H4,97,98,100)/t59-,60-,61-,62-,63-,64-,65-,66-,67-,68-,69-,70-,76-/m0/s1

SMILES Code: [H]N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)NCC(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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2: Hu Z, Zhao T, Chen T, Wang D. Chronic activation of Mas-related gene receptors (Mrg) reduces the potency of morphine-induced analgesia via PKC pathway in naive rats. Brain Res. 2019 Aug 5;1722:146363. doi: 10.1016/j.brainres.2019.146363. [Epub ahead of print] PubMed PMID: 31394092.

3: Sanjel B, Maeng HJ, Shim WS. BAM8-22 and its receptor MRGPRX1 may attribute to cholestatic pruritus. Sci Rep. 2019 Jul 26;9(1):10888. doi: 10.1038/s41598-019-47267-5. PubMed PMID: 31350433; PubMed Central PMCID: PMC6659683.

4: Tsagareli MG, Nozadze I, Tsiklauri N, Gurtskaia G. TRPA1 Channel is Involved in SLIGRL-Evoked Thermal and Mechanical Hyperalgesia in Mice. Med Sci (Basel). 2019 Apr 18;7(4). pii: E62. doi: 10.3390/medsci7040062. PubMed PMID: 31003539; PubMed Central PMCID: PMC6524052.

5: Zhang Y, Wang M, Lu Q, Li Q, Lin M, Huang J, Hong Y. Inhibitory Effects of Mas-Related Gene C Receptor on Chronic Morphine-Induced Spinal Glial Activation in Rats. J Pharmacol Exp Ther. 2019 Feb;368(2):237-245. doi: 10.1124/jpet.118.252494. Epub 2018 Nov 28. PubMed PMID: 30487293.

6: Nozadze I, Tsiklauri N, Gurtskaia G, Tsagareli M. THE ROLE OF TRANSIENT RECEPTOR POTENTIAL (TRPA1) CHANNEL IN PRURITUS. Georgian Med News. 2018 Jul-Aug;(280-281):134-137. PubMed PMID: 30204112.

7: Liu YJ, Lin XX, Fang JQ, Fang F. Involvement of MrgprC in Electroacupuncture Analgesia for Attenuating CFA-Induced Thermal Hyperalgesia by Suppressing the TRPV1 Pathway. Evid Based Complement Alternat Med. 2018 Feb 12;2018:9102107. doi: 10.1155/2018/9102107. eCollection 2018. PubMed PMID: 29619074; PubMed Central PMCID: PMC5829339.

8: Zhang Y, Wang K, Lin M, Li Q, Hong Y. Inhibition of morphine tolerance by MrgC receptor via modulation of interleukin-1β and matrix metalloproteinase 9 in dorsal root ganglia in rats. Eur J Pharmacol. 2017 Nov 15;815:10-17. doi: 10.1016/j.ejphar.2017.10.011. Epub 2017 Oct 6. PubMed PMID: 28993160.

9: Jiang YM, Huang C, Peng Z, Han SL, Li WG, Zhu MX, Xu TL. Acidosis counteracts itch tachyphylaxis to consecutive pruritogen exposure dependent on acid-sensing ion channel 3. Mol Pain. 2017 Jan-Dec;13:1744806917721114. doi: 10.1177/1744806917721114. PubMed PMID: 28745101; PubMed Central PMCID: PMC5533257.

10: Li Z, Tseng PY, Tiwari V, Xu Q, He SQ, Wang Y, Zheng Q, Han L, Wu Z, Blobaum AL, Cui Y, Tiwari V, Sun S, Cheng Y, Huang-Lionnet JH, Geng Y, Xiao B, Peng J, Hopkins C, Raja SN, Guan Y, Dong X. Targeting human Mas-related G protein-coupled receptor X1 to inhibit persistent pain. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):E1996-E2005. doi: 10.1073/pnas.1615255114. Epub 2017 Feb 21. PubMed PMID: 28223516; PubMed Central PMCID: PMC5347560.

11: Akiyama T, Nagamine M, Davoodi A, Ivanov M, Carstens MI, Carstens E. Innocuous warming enhances peripheral serotonergic itch signaling and evokes enhanced responses in serotonin-responsive dorsal horn neurons in the mouse. J Neurophysiol. 2017 Jan 1;117(1):251-259. doi: 10.1152/jn.00703.2016. Epub 2016 Oct 26. PubMed PMID: 27784810; PubMed Central PMCID: PMC5220113.

12: Chang AY, Mann TS, McFawn PK, Han L, Dong X, Henry PJ. Investigating the role of MRGPRC11 and capsaicin-sensitive afferent nerves in the anti-influenza effects exerted by SLIGRL-amide in murine airways. Respir Res. 2016 May 23;17(1):62. doi: 10.1186/s12931-016-0378-8. PubMed PMID: 27215903; PubMed Central PMCID: PMC4877944.

13: Sun Y, Zhang J, Lei Y, Lu C, Hou B, Ma Z, Gu X. Activation of spinal MrgC-Gi-NR2B-nNOS signaling pathway by Mas oncogene-related gene C receptor agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. Am J Transl Res. 2016 Feb 15;8(2):1144-54. eCollection 2016. PubMed PMID: 27158400; PubMed Central PMCID: PMC4846957.

14: Sun Y, Jiang M, Hou B, Lu C, Lei Y, Ma Z, Gu X. Mas-Related Gene (Mrg) C Activation Attenuates Bone Cancer Pain via Modulating Gi and NR2B. PLoS One. 2016 May 6;11(5):e0154851. doi: 10.1371/journal.pone.0154851. eCollection 2016. PubMed PMID: 27152740; PubMed Central PMCID: PMC4859570.

15: Wang D, Xue Y, Yan Y, Lin M, Yang J, Huang J, Hong Y. Reversal of neurochemical alterations in the spinal dorsal horn and dorsal root ganglia by Mas-related gene (Mrg) receptors in a rat model of spinal nerve injury. Neurobiol Dis. 2016 Jul;91:274-83. doi: 10.1016/j.nbd.2016.03.020. Epub 2016 Mar 24. PubMed PMID: 27018398.

16: Wang D, Xue Y, Chen Y, Ruan L, Hong Y. Mas-related gene (Mrg) C receptors inhibit mechanical allodynia and spinal microglia activation in the early phase of neuropathic pain in rats. Neurosci Lett. 2016 Apr 8;618:115-121. doi: 10.1016/j.neulet.2016.03.004. Epub 2016 Mar 4. PubMed PMID: 26952974.

17: Sun YE, Lu CE, Lei Y, Liu Y, Ma Z, Gu X. Mas-related G-protein-coupled receptor c agonist bovine adrenal medulla 8-22 attenuates bone cancer pain in mice. Int J Clin Exp Med. 2015 Nov 15;8(11):20178-87. eCollection 2015. PubMed PMID: 26884930; PubMed Central PMCID: PMC4723775.

18: Kiguchi N, Sukhtankar DD, Ding H, Tanaka K, Kishioka S, Peters CM, Ko MC. Spinal Functions of B-Type Natriuretic Peptide, Gastrin-Releasing Peptide, and Their Cognate Receptors for Regulating Itch in Mice. J Pharmacol Exp Ther. 2016 Mar;356(3):596-603. doi: 10.1124/jpet.115.229997. Epub 2015 Dec 15. PubMed PMID: 26669425; PubMed Central PMCID: PMC4767390.

19: Heller D, Doyle JR, Raman VS, Beinborn M, Kumar K, Kopin AS. Novel Probes Establish Mas-Related G Protein-Coupled Receptor X1 Variants as Receptors with Loss or Gain of Function. J Pharmacol Exp Ther. 2016 Feb;356(2):276-83. doi: 10.1124/jpet.115.227058. Epub 2015 Nov 18. PubMed PMID: 26582731.

20: Jiang JP, Fu Y, Hu FJ, Hong YG. [Activation of spinal MrgC receptors inhibits hyperalgesia in rats]. Sheng Li Xue Bao. 2015 Aug 25;67(4):413-22. Chinese. PubMed PMID: 26300254.