Pamaquine naphthoate

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MedKoo CAT#: 573895

CAS#: 635-05-2

Description: Pamaquine naphthoate is an 8-aminoquinoline drug formerly used for the treatment of malaria.

Price and Availability

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Pricing updated 2020-07-10. Prices are subject to change without notice.

Pamaquine naphthoate is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 573895
Name: Pamaquine naphthoate
CAS#: 635-05-2
Chemical Formula: C42H45N3O7
Exact Mass: 703.3258
Molecular Weight: 703.84
Elemental Analysis: C, 71.67; H, 6.44; N, 5.97; O, 15.91

Synonym: Aminoquin naphthoate, Beprochine naphthoate, Gamefar naphthoate, Pamaquine embonate, Pamaquine naphthoate , Plasmoquine naphthoate

IUPAC/Chemical Name: 2-Naphthoic acid, 4,4'-methylenebis(3-hydroxy-, compd. with 8-((4-(diethylamino)-1-methylbutyl)amino)-6-methoxyquinoline (1:1)


InChi Code: 1S/C23H16O6.C19H29N3O/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29;1-5-22(6-2)12-8-9-15(3)21-18-14-17(23-4)13-16-10-7-11-20-19(16)18/h1-10,24-25H,11H2,(H,26,27)(H,28,29);7,10-11,13-15,21H,5-6,8-9,12H2,1-4H3

SMILES Code: c1(c2c(cc(C(O)=O)c1O)cccc2)Cc1c2c(cc(c1O)C(O)=O)cccc2.c1(c2c(cc(c1)OC)cccn2)N[C@@H](CCCN(CC)CC)C

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: Sweeney AW, Blackburn CR, Rieckmann KH. Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains). Am J Trop Med Hyg. 2004 Aug;71(2):187-9. PubMed PMID: 15306708.

2: Matsuno T, Hariguchi F, Okamoto T. Anticoccidial activity of 8-aminoquinolines, pamaquine, primaquine and several molecular complexes and salts of pamaquine, against Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti in battery experiments. J Vet Med Sci. 1991 Feb;53(1):13-7. PubMed PMID: 1830767.

3: LOKEN AC, HAYMAKER W. Pamaquine poisoning in man, with a clinicopathologic study of one case. Am J Trop Med Hyg. 1949 May;29(3):341-52. PubMed PMID: 18145865.