Brassinazole
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MedKoo CAT#: 330209

CAS#: 224047-41-0

Description: Brassinazole is an inhibitor of brassinosteroid biosynthesis that has been developed in order to probe the myriad functions of brassinosteroids.


Price and Availability

Size
Price

100mg
USD 450
1g
USD 2850
Size
Price

200mg
USD 750
2g
USD 4650
Size
Price

500mg
USD 1650
5g
USD 6450

Brassinazole, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 330209
Name: Brassinazole
CAS#: 224047-41-0
Chemical Formula: C18H18ClN3O
Exact Mass: 327.1138
Molecular Weight: 327.812
Elemental Analysis: C, 65.95; H, 5.53; Cl, 10.81; N, 12.82; O, 4.88


Synonym: Brassinazole ,

IUPAC/Chemical Name: 4-(4-chlorophenyl)-2-phenyl-3-(1H-1,2,4-triazol-1-yl)butan-2-ol

InChi Key: YULDTPKHZNKFEY-UHFFFAOYSA-N

InChi Code: InChI=1S/C18H18ClN3O/c1-18(23,15-5-3-2-4-6-15)17(22-13-20-12-21-22)11-14-7-9-16(19)10-8-14/h2-10,12-13,17,23H,11H2,1H3

SMILES Code: ClC(C=C1)=CC=C1CC(C(C)(O)C2=CC=CC=C2)N3N=CN=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Derevyanchuk M, Kretynin S, Kolesnikov Y, Litvinovskaya R, Martinec J, Khripach V, Kravets V. Seed germination, respiratory processes and phosphatidic acid accumulation in Arabidopsis diacylglycerol kinase knockouts - The effect of brassinosteroid, brassinazole and salinity. Steroids. 2019 Jul;147:28-36. doi: 10.1016/j.steroids.2019.04.002. Epub 2019 Apr 11. PubMed PMID: 30981682.

2: Gao J, Yu M, Zhu S, Zhou L, Liu S. Effects of exogenous 24-epibrassinolide and brassinazole on negative gravitropism and tension wood formation in hybrid poplar (Populus deltoids × Populus nigra). Planta. 2019 May;249(5):1449-1463. doi: 10.1007/s00425-018-03074-2. Epub 2019 Jan 28. PubMed PMID: 30689054.

3: Bajguz A, Orczyk W, Gołębiewska A, Chmur M, Piotrowska-Niczyporuk A. Occurrence of brassinosteroids and influence of 24-epibrassinolide with brassinazole on their content in the leaves and roots of Hordeum vulgare L. cv. Golden Promise. Planta. 2019 Jan;249(1):123-137. doi: 10.1007/s00425-018-03081-3. Epub 2018 Dec 29. PubMed PMID: 30594955.

4: Fan C, Guo G, Yan H, Qiu Z, Liu Q, Zeng B. Characterization of Brassinazole resistant (BZR) gene family and stress induced expression in Eucalyptus grandis. Physiol Mol Biol Plants. 2018 Sep;24(5):821-831. doi: 10.1007/s12298-018-0543-2. Epub 2018 Jun 18. PubMed PMID: 30150857; PubMed Central PMCID: PMC6103948.

5: Tian Y, Fan M, Qin Z, Lv H, Wang M, Zhang Z, Zhou W, Zhao N, Li X, Han C, Ding Z, Wang W, Wang ZY, Bai MY. Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor. Nat Commun. 2018 Mar 14;9(1):1063. doi: 10.1038/s41467-018-03463-x. PubMed PMID: 29540799; PubMed Central PMCID: PMC5852159.

6: Yang X, Bai Y, Shang J, Xin R, Tang W. The antagonistic regulation of abscisic acid-inhibited root growth by brassinosteroids is partially mediated via direct suppression of ABSCISIC ACID INSENSITIVE 5 expression by BRASSINAZOLE RESISTANT 1. Plant Cell Environ. 2016 Sep;39(9):1994-2003. doi: 10.1111/pce.12763. Epub 2016 Jul 15. PubMed PMID: 27149247.

7: Lee HS, Kim Y, Pham G, Kim JW, Song JH, Lee Y, Hwang YS, Roux SJ, Kim SH. Brassinazole resistant 1 (BZR1)-dependent brassinosteroid signalling pathway leads to ectopic activation of quiescent cell division and suppresses columella stem cell differentiation. J Exp Bot. 2015 Aug;66(15):4835-49. doi: 10.1093/jxb/erv316. Epub 2015 Jul 1. PubMed PMID: 26136267; PubMed Central PMCID: PMC4507784.

8: Singh AP, Fridman Y, Friedlander-Shani L, Tarkowska D, Strnad M, Savaldi-Goldstein S. Activity of the brassinosteroid transcription factors BRASSINAZOLE RESISTANT1 and BRASSINOSTEROID INSENSITIVE1-ETHYL METHANESULFONATE-SUPPRESSOR1/BRASSINAZOLE RESISTANT2 blocks developmental reprogramming in response to low phosphate availability. Plant Physiol. 2014 Oct;166(2):678-88. doi: 10.1104/pp.114.245019. Epub 2014 Aug 18. PubMed PMID: 25136063; PubMed Central PMCID: PMC4213097.

9: Zhang Y, Li B, Xu Y, Li H, Li S, Zhang D, Mao Z, Guo S, Yang C, Weng Y, Chong K. The cyclophilin CYP20-2 modulates the conformation of BRASSINAZOLE-RESISTANT1, which binds the promoter of FLOWERING LOCUS D to regulate flowering in Arabidopsis. Plant Cell. 2013 Jul;25(7):2504-21. doi: 10.1105/tpc.113.110296. Epub 2013 Jul 29. PubMed PMID: 23897924; PubMed Central PMCID: PMC3753379.

10: Pereira-Netto AB, Roessner U, Fujioka S, Bacic A, Asami T, Yoshida S, Clouse SD. Shooting control by brassinosteroids: metabolomic analysis and effect of brassinazole on Malus prunifolia, the Marubakaido apple rootstock. Tree Physiol. 2009 Apr;29(4):607-20. doi: 10.1093/treephys/tpn052. Epub 2009 Feb 2. PubMed PMID: 19203977.

11: Bajguz A, Asami T. Suppression of Wolffia arrhiza growth by brassinazole, an inhibitor of brassinosteroid biosynthesis and its restoration by endogenous 24-epibrassinolide. Phytochemistry. 2005 Aug;66(15):1787-96. PubMed PMID: 16038953.

12: Bajguz A, Asami T. Effects of brassinazole, an inhibitor of brassinosteroid biosynthesis, on light- and dark-grown Chlorella vulgaris. Planta. 2004 Mar;218(5):869-77. Epub 2003 Dec 4. PubMed PMID: 14655015.

13: Nagata N, Asami T, Yoshida S. Brassinazole, an inhibitor of brassinosteroid biosynthesis, inhibits development of secondary xylem in cress plants (Lepidium sativum). Plant Cell Physiol. 2001 Sep;42(9):1006-11. PubMed PMID: 11577196.

14: Nagata N, Min YK, Nakano T, Asami T, Yoshida S. Treatment of dark-grown Arabidopsis thaliana with a brassinosteroid-biosynthesis inhibitor, brassinazole, induces some characteristics of light-grown plants. Planta. 2000 Nov;211(6):781-90. PubMed PMID: 11144262.

15: Asami T, Min YK, Nagata N, Yamagishi K, Takatsuto S, Fujioka S, Murofushi N, Yamaguchi I, Yoshida S. Characterization of brassinazole, a triazole-type brassinosteroid biosynthesis inhibitor. Plant Physiol. 2000 May;123(1):93-100. PubMed PMID: 10806228; PubMed Central PMCID: PMC58985.