Pamaquine

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573894

CAS#: 491-92-9 (free base)

Description: Pamaquine is an 8-aminoquinoline drug formerly used for the treatment of malaria.

Chemical Structure

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Pamaquine
CAS# 491-92-9 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 573894
Name: Pamaquine
CAS#: 491-92-9 (free base)
Chemical Formula: C19H29N3O
Exact Mass: 315.23
Molecular Weight: 315.460
Elemental Analysis: C, 72.34; H, 9.27; N, 13.32; O, 5.07

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 63680-62-6 (HCl); 635-05-2 (naphthoate); 491-92-9 (free base)  

Synonym: Aminoquin, Beprochine, Pamaquine, Plasmoquine, Quipenyl, Rhodoquine

IUPAC/Chemical Name: N(1),N(1)-Diethyl-N(4)-(6-methoxy-8-quinolinyl)-1,4-pentanediamine

InChi Key: QTQWMSOQOSJFBV-UHFFFAOYSA-N

InChi Code: 1S/C19H29N3O/c1-5-22(6-2)12-8-9-15(3)21-18-14-17(23-4)13-16-10-7-11-20-19(16)18/h7,10-11,13-15,21H,5-6,8-9,12H2,1-4H3

SMILES Code: CCN(CC)CCCC(C)Nc1cc(OC)cc2cccnc12

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 315.46 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sweeney AW, Blackburn CR, Rieckmann KH. Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains). Am J Trop Med Hyg. 2004 Aug;71(2):187-9. PubMed PMID: 15306708.

2: Matsuno T, Hariguchi F, Okamoto T. Anticoccidial activity of 8-aminoquinolines, pamaquine, primaquine and several molecular complexes and salts of pamaquine, against Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti in battery experiments. J Vet Med Sci. 1991 Feb;53(1):13-7. PubMed PMID: 1830767.

3: LOKEN AC, HAYMAKER W. Pamaquine poisoning in man, with a clinicopathologic study of one case. Am J Trop Med Hyg. 1949 May;29(3):341-52. PubMed PMID: 18145865.