Pamaquine

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MedKoo CAT#: 573894

CAS#: 491-92-9

Description: Pamaquine is an 8-aminoquinoline drug formerly used for the treatment of malaria.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

Pamaquine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 573894
Name: Pamaquine
CAS#: 491-92-9
Chemical Formula: C19H29N3O
Exact Mass: 315.2311
Molecular Weight: 315.46
Elemental Analysis: C, 72.34; H, 9.27; N, 13.32; O, 5.07


Synonym: Aminoquin, Beprochine, Pamaquine, Plasmoquine, Quipenyl, Rhodoquine

IUPAC/Chemical Name: N(1),N(1)-Diethyl-N(4)-(6-methoxy-8-quinolinyl)-1,4-pentanediamine

InChi Key: QTQWMSOQOSJFBV-UHFFFAOYSA-N

InChi Code: 1S/C19H29N3O/c1-5-22(6-2)12-8-9-15(3)21-18-14-17(23-4)13-16-10-7-11-20-19(16)18/h7,10-11,13-15,21H,5-6,8-9,12H2,1-4H3

SMILES Code: CCN(CC)CCCC(C)Nc1cc(OC)cc2cccnc12


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Sweeney AW, Blackburn CR, Rieckmann KH. Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains). Am J Trop Med Hyg. 2004 Aug;71(2):187-9. PubMed PMID: 15306708.

2: Matsuno T, Hariguchi F, Okamoto T. Anticoccidial activity of 8-aminoquinolines, pamaquine, primaquine and several molecular complexes and salts of pamaquine, against Eimeria tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti in battery experiments. J Vet Med Sci. 1991 Feb;53(1):13-7. PubMed PMID: 1830767.

3: LOKEN AC, HAYMAKER W. Pamaquine poisoning in man, with a clinicopathologic study of one case. Am J Trop Med Hyg. 1949 May;29(3):341-52. PubMed PMID: 18145865.