WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555600

CAS#: Unknown

Description: JMX0254 is a Potent NS4B Inhibitor for the Treatment of Dengue Virus Infection. JMX0254 displayed the most potent and broad inhibitory activities, effective against DENV-1 to -3 with EC50 values of 0.78, 0.16, and 0.035 μM, respectively. JMX0254 exhibited good in vivo pharmacokinetic properties and efficacy in the A129 mouse model.

Chemical Structure

CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 555600
Name: JMX0254
CAS#: Unknown
Chemical Formula: C25H25Cl2N5O2
Exact Mass: 497.1385
Molecular Weight: 498.408
Elemental Analysis: C, 60.25; H, 5.06; Cl, 14.23; N, 14.05; O, 6.42

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: JMX0254; JMX-0254; JMX 0254;

IUPAC/Chemical Name: (R)-5-Chloro-3'-((S)-1-(4-chlorophenyl)ethyl)-1-isopentyl-3',4'-dihydrospiro[indoline-3,7'-[1,2,3]triazolo[4,5-b]pyridine]-2,5'(6'H)-dione


InChi Code: InChI=1S/C25H25Cl2N5O2/c1-14(2)10-11-31-20-9-8-18(27)12-19(20)25(24(31)34)13-21(33)28-23-22(25)29-30-32(23)15(3)16-4-6-17(26)7-5-16/h4-9,12,14-15H,10-11,13H2,1-3H3,(H,28,33)/t15-,25+/m0/s1

SMILES Code: O=C1N(CCC(C)C)C2=C(C=C(Cl)C=C2)[C@]13C(N=NN4[C@H](C5=CC=C(Cl)C=C5)C)=C4NC(C3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 498.408 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Xu J, Xie X, Ye N, Zou J, Chen H, White MA, Shi PY, Zhou J. Design, Synthesis,
and Biological Evaluation of Substituted
Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection.
J Med Chem. 2019 Aug 23. doi: 10.1021/acs.jmedchem.9b00698. [Epub ahead of print]
PubMed PMID: 31403780.