WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555600
Description: JMX0254 is a Potent NS4B Inhibitor for the Treatment of Dengue Virus Infection. JMX0254 displayed the most potent and broad inhibitory activities, effective against DENV-1 to -3 with EC50 values of 0.78, 0.16, and 0.035 μM, respectively. JMX0254 exhibited good in vivo pharmacokinetic properties and efficacy in the A129 mouse model.
MedKoo Cat#: 555600
Chemical Formula: C25H25Cl2N5O2
Exact Mass: 497.1385
Molecular Weight: 498.408
Elemental Analysis: C, 60.25; H, 5.06; Cl, 14.23; N, 14.05; O, 6.42
This product is not in stock, which may be available by custom synthesis.
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Synonym: JMX0254; JMX-0254; JMX 0254;
IUPAC/Chemical Name: (R)-5-Chloro-3'-((S)-1-(4-chlorophenyl)ethyl)-1-isopentyl-3',4'-dihydrospiro[indoline-3,7'-[1,2,3]triazolo[4,5-b]pyridine]-2,5'(6'H)-dione
InChi Key: UCOQXTLXEBGWHG-ODCWNRFASA-N
InChi Code: InChI=1S/C25H25Cl2N5O2/c1-14(2)10-11-31-20-9-8-18(27)12-19(20)25(24(31)34)13-21(33)28-23-22(25)29-30-32(23)15(3)16-4-6-17(26)7-5-16/h4-9,12,14-15H,10-11,13H2,1-3H3,(H,28,33)/t15-,25+/m0/s1
SMILES Code: O=C1N(CCC(C)C)C2=C(C=C(Cl)C=C2)[C@]13C(N=NN4[C@H](C5=CC=C(Cl)C=C5)C)=C4NC(C3)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 498.408 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Xu J, Xie X, Ye N, Zou J, Chen H, White MA, Shi PY, Zhou J. Design, Synthesis,
and Biological Evaluation of Substituted
Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection.
J Med Chem. 2019 Aug 23. doi: 10.1021/acs.jmedchem.9b00698. [Epub ahead of print]
PubMed PMID: 31403780.