WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573873
CAS#: 60573-88-8
Description: Ibotenic acid hydrate is a neurotoxic isoxazole (similar to Kainic acid and Muscimol) found in Amanita mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
MedKoo Cat#: 573873
Name: Ibotenic acid hydrate
CAS#: 60573-88-8
Chemical Formula: C5H8N2O5
Exact Mass: 176.0433
Molecular Weight: 176.13
Elemental Analysis: C, 34.10; H, 4.58; N, 15.91; O, 45.42
Synonym: Ibotenic acid hydrate, Pramuscimol
IUPAC/Chemical Name: 5-Isoxazoleacetic acid, alpha-amino-3-hydroxy-, monohydrate
InChi Key: QVKQQLYSTODTJN-UHFFFAOYSA-N
InChi Code: 1S/C5H6N2O4.H2O/c6-4(5(9)10)2-1-3(8)7-11-2;/h1,4H,6H2,(H,7,8)(H,9,10);1H2
SMILES Code: O.NC(C(=O)O)c1onc(O)c1
1: Frydenvang K, Pickering DS, Greenwood JR, Krogsgaard-Larsen N, Brehm L, Nielsen B, Vogensen SB, Hald H, Kastrup JS, Krogsgaard-Larsen P, Clausen RP. Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. J Med Chem. 2010 Dec 9;53(23):8354-61. doi: 10.1021/jm101218a. Epub 2010 Nov 10. PubMed PMID: 21067182.
2: Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia. J Comp Neurol. 2008 Jun 1;508(4):648-62. doi: 10.1002/cne.21685. PubMed PMID: 18383504; PubMed Central PMCID: PMC4924624.
3: Hansson E. Metabotropic glutamate receptor activation induces astroglial swelling. J Biol Chem. 1994 Sep 2;269(35):21955-61. PubMed PMID: 7915278.