WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573873
Description: Ibotenic acid hydrate is a neurotoxic isoxazole (similar to Kainic acid and Muscimol) found in Amanita mushrooms. It causes motor depression, ataxia, and changes in mood, perceptions and feelings, and is a potent excitatory amino acid agonist.
MedKoo Cat#: 573873
Name: Ibotenic acid hydrate
Chemical Formula: C5H8N2O5
Exact Mass: 176.0433
Molecular Weight: 176.13
Elemental Analysis: C, 34.10; H, 4.58; N, 15.91; O, 45.42
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Ibotenic acid hydrate, Pramuscimol
IUPAC/Chemical Name: 5-Isoxazoleacetic acid, alpha-amino-3-hydroxy-, monohydrate
InChi Key: QVKQQLYSTODTJN-UHFFFAOYSA-N
InChi Code: 1S/C5H6N2O4.H2O/c6-4(5(9)10)2-1-3(8)7-11-2;/h1,4H,6H2,(H,7,8)(H,9,10);1H2
SMILES Code: O.NC(C(=O)O)c1onc(O)c1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 176.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Frydenvang K, Pickering DS, Greenwood JR, Krogsgaard-Larsen N, Brehm L, Nielsen B, Vogensen SB, Hald H, Kastrup JS, Krogsgaard-Larsen P, Clausen RP. Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid. J Med Chem. 2010 Dec 9;53(23):8354-61. doi: 10.1021/jm101218a. Epub 2010 Nov 10. PubMed PMID: 21067182.
2: Lu J, Nelson LE, Franks N, Maze M, Chamberlin NL, Saper CB. Role of endogenous sleep-wake and analgesic systems in anesthesia. J Comp Neurol. 2008 Jun 1;508(4):648-62. doi: 10.1002/cne.21685. PubMed PMID: 18383504; PubMed Central PMCID: PMC4924624.
3: Hansson E. Metabotropic glutamate receptor activation induces astroglial swelling. J Biol Chem. 1994 Sep 2;269(35):21955-61. PubMed PMID: 7915278.