WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555598
Description: KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts.
MedKoo Cat#: 555598
Chemical Formula: C14H12N2O2
Exact Mass: 240.0899
Molecular Weight: 240.262
Elemental Analysis: C, 69.99; H, 5.03; N, 11.66; O, 13.32
Synonym: KL-1333; KL 1333; KL1333;
IUPAC/Chemical Name: 2-(1-Methylethyl)-3H-naphth(1,2-d)imidazole-4,5-dione
InChi Key: AJFWITSBVLLDCC-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H12N2O2/c1-7(2)14-15-10-8-5-3-4-6-9(8)12(17)13(18)11(10)16-14/h3-7H,1-2H3,(H,15,16)
SMILES Code: O=C(C1=C2N=C(C(C)C)N1)C(C3=C2C=CC=C3)=O
Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS), one of the most common maternally inherited mitochondrial diseases, is caused by mitochondrial DNA mutations that lead to mitochondrial dysfunction. Several treatment options exist, including supplementation with CoQ10, vitamins, and nutrients, but no treatment with proven efficacy is currently available.