Thiocolchicoside
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585077

CAS#: 602-41-5

Description: Thiocolchicoside is used in combination with glafenine and meprobamate to tranquilize patients undergoing hysterosalpingography.

Chemical Structure

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Thiocolchicoside
CAS# 602-41-5
Instruction

Theoretical Analysis

MedKoo Cat#: 585077
Name: Thiocolchicoside
CAS#: 602-41-5
Chemical Formula: C27H33NO10S
Exact Mass: 563.18
Molecular Weight: 563.618
Elemental Analysis: C, 57.54; H, 5.90; N, 2.49; O, 28.39; S, 5.69

Price and Availability

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20mg USD 420
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Synonym: Thiocolchicoside; R. 271; Coltramyl

IUPAC/Chemical Name: 2-10-Di(demethoxy)-2-glucosyloxy-10-methylthiocolchicine

InChi Key: LEQAKWQJCITZNK-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H33NO10S/c1-12(30)28-16-7-5-13-9-18(37-27-24(34)23(33)22(32)19(11-29)38-27)25(35-2)26(36-3)21(13)14-6-8-20(39-4)17(31)10-15(14)16/h6,8-10,16,19,22-24,27,29,32-34H,5,7,11H2,1-4H3,(H,28,30)

SMILES Code: COC1=C2C3=CC=C(C(C=C3C(CCC2=CC(OC4OC(C(C(O)C4O)O)CO)=C1OC)NC(C)=O)=O)SC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 563.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yilmaz F, Günen Yılmaz S, Keleş M. Thiocolchicoside associated with epileptic seizures in a chronic hemodialysis patient. Saudi J Kidney Dis Transpl. 2019 Mar-Apr;30(2):513-516. doi: 10.4103/1319-2442.256859. PubMed PMID: 31031388.

2: Bourazani M, Papageorgiou E, Zarkadas G, Petrakopoulou T, Kaba E, Fasoi G, Kelesi M. The Role of Muscle Relaxants – Spasmolytic (Thiocochlicoside) in Postoperative Pain Management after Mastectomy and Breast Reconstruction. Asian Pac J Cancer Prev. 2019 Mar 26;20(3):743-749. PubMed PMID: 30909680.

3: Mutha VVSRNAK, RavichandraReddy VV, Achanta PS, Rendedula D, Chandra C, Shaik NM, Kaliyaperumal M, Korupolu RB, Gajbhiye SB, Rumalla CS. Structure elucidation of novel degradation products of thiocolchicoside by NMR spectroscopy. J Pharm Biomed Anal. 2019 Apr 15;167:49-58. doi: 10.1016/j.jpba.2018.12.048. Epub 2019 Jan 31. PubMed PMID: 30739051.

4: Csiba L, Zhussupova AS, Likhachev SA, Parfenov VA, Churyukanov MV, Guekht AB. [A systematic review of using myorelaxants in treatment of low back pain]. Zh Nevrol Psikhiatr Im S S Korsakova. 2018;118(12):100-113. doi: 10.17116/jnevro2018118121100. Russian. PubMed PMID: 30698569.

5: Cigerim L, Kaplan V. Evaluation of the analgesic efficacies of Dexketoprofen Trometamol and Dexketoprofen Trometamol + Thiocolchicoside combinations in the impacted third molar surgery: Randomised clinical trial. Med Oral Patol Oral Cir Bucal. 2019 Jan 1;24(1):e114-e122. doi: 10.4317/medoral.22590. PubMed PMID: 30573719; PubMed Central PMCID: PMC6344008.

6: Mancuso G. Immediate and delayed contact hypersensitivity to thiocolchicoside. Acta Dermatovenerol Alp Pannonica Adriat. 2018 Dec;27(4):203-205. PubMed PMID: 30564833.

7: Imberti R, De Gregori S, Rabaglia L, Regazzi M. Bioavailability of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg single dose vs. single components. Minerva Med. 2019 Jun;110(3):264-267. doi: 10.23736/S0026-4806.18.05854-8. Epub 2018 Nov 27. PubMed PMID: 30484591.

8: Altan L, Kasapoğlu Aksoy M, Kösegil Öztürk E. Efficacy of diclofenac & thiocolchioside gel phonophoresis comparison with ultrasound therapy on acute low back pain; a prospective, double-blind, randomized clinical study. Ultrasonics. 2019 Jan;91:201-205. doi: 10.1016/j.ultras.2018.08.008. Epub 2018 Aug 16. PubMed PMID: 30139568.

9: Kaplan YC, Keskin-Arslan E, Küçüksolak G, Akyol F, Karadas B, Görgel SN, Kaya-Temiz T. Pregnancy outcomes after maternal use of thiocolchicoside: A case series. Reprod Toxicol. 2018 Mar;76:103-108. doi: 10.1016/j.reprotox.2018.01.003. Epub 2018 Jan 31. PubMed PMID: 29378258.

10: Sproviero E, Albamonte E, Costantino C, Giossi A, Mancuso M, Rigamonti A, Tornari P, Caggiano G. Efficacy and safety of a fixed combination of intramuscular diclofenac 75 mg + thiocolchicoside 4 mg in the treatment of acute low back pain: a phase III, randomized, double blind, controlled trial. Eur J Phys Rehabil Med. 2018 Oct;54(5):654-662. doi: 10.23736/S1973-9087.17.04923-1. Epub 2017 Dec 21. PubMed PMID: 29265793.

11: Alves JC, Dos Santos AM, Fernandes ÂD. Evaluation of the effect of mesotherapy in the management of back pain in police working dog. Vet Anaesth Analg. 2018 Jan;45(1):123-128. doi: 10.1016/j.vaa.2017.07.006. Epub 2017 Aug 19. PubMed PMID: 29222031.

12: Asil S, Canpolat U, Kaya EB, Aytemir K, Kabakçı G. Case series of three different scenarios with drug-induced Brugada patterns: fact or fiction? Turk Kardiyol Dern Ars. 2017 Oct;45(7):650-654. doi: 10.5543/tkda.2017.02717. PubMed PMID: 28990948.

13: Alves JC, Santos AM. Evaluation of the Effect of Mesotherapy in the Management of Osteoarthritis-Related Pain in a Police Working Dog Using the Canine Brief Pain Inventory. Top Companion Anim Med. 2017 Mar;32(1):41-43. doi: 10.1053/j.tcam.2017.07.002. Epub 2017 Jul 5. PubMed PMID: 28750790.

14: Gervasi M, Sisti D, Benelli P, Fernández-Peña E, Calcabrini C, Rocchi MBL, Lanata L, Bagnasco M, Tonti A, Vilberto S, Sestili P. The effect of topical thiocolchicoside in preventing and reducing the increase of muscle tone, stiffness, and soreness: A real-life study on top-level road cyclists during stage competition. Medicine (Baltimore). 2017 Jul;96(30):e7659. doi: 10.1097/MD.0000000000007659. PubMed PMID: 28746232; PubMed Central PMCID: PMC5627858.

15: Pageot C, Bezin J, Smith A, Arnaud M, Salvo F, Haramburu F, Bégaud B, Pariente A; French Network of Pharmacovigilance Centres. Impact of Medicine Withdrawal on Reporting of Adverse Events Involving Therapeutic Alternatives: A Study from the French Spontaneous Reporting Database. Drug Saf. 2017 Nov;40(11):1099-1107. doi: 10.1007/s40264-017-0561-y. PubMed PMID: 28664354.

16: Havali C, Gucuyener K, Gurkas E, Demir E. Temporary Seizure in an Infant Who Had Been Exposed to G-Amino Butyric Acid Receptor Antagonist Thiocolchicoside. Pediatr Emerg Care. 2019 May;35(5):e96-e97. doi: 10.1097/PEC.0000000000001161. PubMed PMID: 28486264.

17: Amaral L, Carolino F, Carneiro-Leão L, Dias de Castro E, Cernadas JR. Thiocolchicoside: An unusual suspect of drug hypersensitivity. J Allergy Clin Immunol Pract. 2017 Nov - Dec;5(6):1750-1751. doi: 10.1016/j.jaip.2017.03.018. Epub 2017 Apr 19. PubMed PMID: 28433341.

18: Kumar A, Mondal S, Sethi P, Manchanda S, Biswas A, Wig N. Spontaneous iliopsoas haematoma in a patient with dengue haemorrhagic fever (DHF): A case report. J Vector Borne Dis. 2017 Jan-Mar;54(1):103-105. PubMed PMID: 28352053.

19: Arslan HH, Cebeci S, Yildizoglu U, Pusat S, Yavuz F. Effects of thiocolchicoside, a commonly used myorelaxant, on the acoustic reflex. J Laryngol Otol. 2017 Jun;131(6):497-500. doi: 10.1017/S0022215117000512. Epub 2017 Mar 2. PubMed PMID: 28249630.

20: Lepelley M, Mallaret M. Benzodiazepine withdrawal syndrome induced by thiocolchicoside. Eur Neuropsychopharmacol. 2017 Mar;27(3):291-292. doi: 10.1016/j.euroneuro.2017.01.004. Epub 2017 Jan 17. PubMed PMID: 28108061.