WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 558694
CAS#: 376616-73-8
Description: 2-HTP is a potent orthosteric and allosteric agonist of GPR84.
MedKoo Cat#: 558694
Name: 2-HTP
CAS#: 376616-73-8
Chemical Formula: C10H16N2O2S
Exact Mass: 228.0932
Molecular Weight: 228.31
Elemental Analysis: C, 52.61; H, 7.06; N, 12.27; O, 14.02; S, 14.04
Synonym: 2HTP; 2 HTP; 2-HTP; ZQ16; ZQ 16; ZQ-16
IUPAC/Chemical Name: 2-(Hexylthio)pyrimidine-4,6 diol
InChi Key: UYXOAKRMLQKLQX-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H16N2O2S/c1-2-3-4-5-6-15-10-11-8(13)7-9(14)12-10/h7H,2-6H2,1H3,(H2,11,12,13,14)
SMILES Code: OC1=NC(SCCCCCC)=NC(O)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 228.31 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Mancini SJ, Mahmud ZA, Jenkins L, Bolognini D, Newman R, Barnes M, Edye ME, McMahon SB, Tobin AB, Milligan G. On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Sci Rep. 2019 Feb 12;9(1):1861. doi: 10.1038/s41598-019-38539-1. PubMed PMID: 30755705; PubMed Central PMCID: PMC6372602.
2: Epe B, Ballmaier D, Adam W, Grimm GN, Saha-Möller CR. Photolysis of N-hydroxpyridinethiones: a new source of hydroxyl radicals for the direct damage of cell-free and cellular DNA. Nucleic Acids Res. 1996 May 1;24(9):1625-31. PubMed PMID: 8649978; PubMed Central PMCID: PMC145837.
