JTP 103237 | CAS#1883864-16-1 | inhibitor

JTP 103237
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 585073

CAS#: 1883864-16-1

Description: JTP 103237 is a potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor.

Chemical Structure

JTP 103237

CAS# 1883864-16-1

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 585073
Name: JTP 103237
CAS#: 1883864-16-1
Chemical Formula: C24H29F3N6O
Exact Mass: 474.24
Molecular Weight: 474.532
Elemental Analysis: C, 60.75; H, 6.16; F, 12.01; N, 17.71; O, 3.37

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 450	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: JTP 103237; JTP103237; JTP-103237

IUPAC/Chemical Name: 7-[4,6-Bis(1,1-dimethylethyl)-2-pyrimidinyl]-5,6,7,8-tetrahydro-3-[4-(trifluoromethoxy)phenyl]-1,2,4-triazolo[4,3-a]pyrazine

InChi Key: KELNXHBJTXCXSN-UHFFFAOYSA-N

InChi Code: InChI=1S/C24H29F3N6O/c1-22(2,3)17-13-18(23(4,5)6)29-21(28-17)32-11-12-33-19(14-32)30-31-20(33)15-7-9-16(10-8-15)34-24(25,26)27/h7-10,13H,11-12,14H2,1-6H3

SMILES Code: FC(F)(F)OC1=CC=C(C2=NN=C3CN(C4=NC(C(C)(C)C)=CC(C(C)(C)C)=N4)CCN32)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

View handling instruction

Biological target:	Potent and selective monoacyglycerol acyltransferase 2 (MOGAT2) inhibitor.
In vitro activity:	TBD
In vivo activity:	In the present study, JTP-103237 prevented carbohydrate-induced fatty liver and suppressed both TG synthesis and de novo lipogenesis, suggesting MGAT inhibitor may prevent carbohydrate-induced metabolic disorders, including NAFLD, obesity and diabetes. The results showed that JTP-103237 significantly decreased hepatic triglyceride (45.0 ± 5.5 mg/g liver in vehicle group and 27.1 ± 7.3 mg/g liver, respectively. P < 0.01 in Student's t-test) in mice. Reference: J Pharmacol Sci. 2015 Jul;128(3):150-7. https://pubmed.ncbi.nlm.nih.gov/26215699/

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	DMSO	9.5	20.00
	Ethanol	47.5	100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 474.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Okuma C, Ohta T, Tadaki H, Ishigure T, Sakata S, Taniuchi H, Sano R, Hamada H, Kume S, Nishiu J, Kakutani M. JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J Pharmacol Sci. 2015 Jul;128(3):150-7. doi: 10.1016/j.jphs.2015.06.007. Epub 2015 Jul 2. PMID: 26215699.
In vitro protocol:	TBD
In vivo protocol:	1. Okuma C, Ohta T, Tadaki H, Ishigure T, Sakata S, Taniuchi H, Sano R, Hamada H, Kume S, Nishiu J, Kakutani M. JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J Pharmacol Sci. 2015 Jul;128(3):150-7. doi: 10.1016/j.jphs.2015.06.007. Epub 2015 Jul 2. PMID: 26215699.

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Okuma et al (2015) JTP-103237, a novel monoacylglycerol acyltransferase inhibitor, modulates fat absorption and prevents diet-induced obesity. Eur.J.Pharmacol. 758 72 PMID: 25857225

Okuma et al (2015) JTP-103237, a monoacylglycerol acyltransferase inhibitor, prevents fatty liver and suppresses both triglyceride synthesis and de novo lipogenesis. J.Pharmacol.Sci. 128 150 PMID: 26215699

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