A-779
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MedKoo CAT#: 555596

CAS#: 159432-28-7

Description: A-779 is a peptide antagonist of the Mas receptor, also known as the angiotensin (1-7) (Ang (1-7)) receptor (IC50 = 0.3 nM in a radioligand binding assay). A-779 attenuates the potentiation of bradykinin by captopril in rats.


Price and Availability

Size
Price

10mg
USD 310
Size
Price

25mg
USD 550
Size
Price

100mg
USD 1450

A-779, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555596
Name: A-779
CAS#: 159432-28-7
Chemical Formula: C39H60N12O11
Exact Mass: 872.4505
Molecular Weight: 872.982
Elemental Analysis: C, 53.66; H, 6.93; N, 19.25; O, 20.16


Synonym: A-779; A 779; A779; (D-Ala7)-Angiotensin I/II (1-7); Asp-Arg-Val-Tyr-Ile-His-D-Ala-OH; 5-L-isoleucine-7-D-alanine-1-7-angiotensin II;

IUPAC/Chemical Name: (2R,5S,8S,11S,14S,17S,20S)-5-((1H-imidazol-4-yl)methyl)-20-amino-8-((S)-sec-butyl)-17-(3-guanidinopropyl)-11-(4-hydroxybenzyl)-14-isopropyl-2-methyl-4,7,10,13,16,19-hexaoxo-3,6,9,12,15,18-hexaazadocosanedioic acid

InChi Key: GZSZZUXDAPDPOR-NGIFJXEWSA-N

InChi Code: InChI=1S/C39H60N12O11/c1-6-20(4)31(37(60)49-28(15-23-17-43-18-45-23)34(57)46-21(5)38(61)62)51-35(58)27(14-22-9-11-24(52)12-10-22)48-36(59)30(19(2)3)50-33(56)26(8-7-13-44-39(41)42)47-32(55)25(40)16-29(53)54/h9-12,17-21,25-28,30-31,52H,6-8,13-16,40H2,1-5H3,(H,43,45)(H,46,57)(H,47,55)(H,48,59)(H,49,60)(H,50,56)(H,51,58)(H,53,54)(H,61,62)(H4,41,42,44)/t20-,21+,25-,26-,27-,28-,30-,31-/m0/s1

SMILES Code: O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=C(C=C1)O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CNC=N2)C(N[C@H](C)C(O)=O)=O)=O)=O)=O)=O)[C@H](CC(O)=O)N


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Banday AA, Diaz Diaz A, Lokhandwala M. Kidney Dopamine D1-like Receptors and Angiotensin 1-7 Interaction Inhibits Renal Sodium Transporters. Am J Physiol Renal Physiol. 2019 Aug 14. doi: 10.1152/ajprenal.00135.2019. [Epub ahead of print] PubMed PMID: 31411069.

2: Costa-Ferreira W, Gomes-de-Souza L, Crestani CC. AT(2) and MAS (but not AT(1)) angiotensinergic receptors in the medial amygdaloid nucleus modulate the baroreflex activity in rats. Pflugers Arch. 2019 Aug 8. doi: 10.1007/s00424-019-02301-3. [Epub ahead of print] PubMed PMID: 31396758.

3: Stamatakis E, Straker L, Hamer M, Gebel K. The 2018 Physical Activity Guidelines for Americans: What's New? Implications for Clinicians and the Public. J Orthop Sports Phys Ther. 2019 Jul;49(7):487-490. doi: 10.2519/jospt.2019.0609. PubMed PMID: 31258047.

4: Zhang F, Tang H, Sun S, Luo Y, Ren X, Chen A, Xu Y, Li P, Han Y. Angiotensin-(1-7) induced vascular relaxation in spontaneously hypertensive rats. Nitric Oxide. 2019 Jul 1;88:1-9. doi: 10.1016/j.niox.2019.03.007. Epub 2019 Mar 14. PubMed PMID: 30880106.

5: Yan D, Li G, Zhang Y, Liu Y. Angiotensin-converting enzyme 2 activation suppresses pulmonary vascular remodeling by inducing apoptosis through the Hippo signaling pathway in rats with pulmonary arterial hypertension. Clin Exp Hypertens. 2019;41(6):589-598. doi: 10.1080/10641963.2019.1583247. Epub 2019 Feb 26. PubMed PMID: 30806090.

6: Zambelli V, Sigurtà A, Rizzi L, Zucca L, Delvecchio P, Bresciani E, Torsello A, Bellani G. Angiotensin-(1-7) exerts a protective action in a rat model of ventilator-induced diaphragmatic dysfunction. Intensive Care Med Exp. 2019 Jan 18;7(1):8. doi: 10.1186/s40635-018-0218-x. PubMed PMID: 30659381; PubMed Central PMCID: PMC6338614.

7: Jiang M, Huang W, Wang Z, Ren F, Luo L, Zhou J, Yan R, Xia N, Tang L. Anti-inflammatory effects of Ang-(1-7) via TLR4-mediated inhibition of the JNK/FoxO1 pathway in lipopolysaccharide-stimulated RAW264.7 cells. Dev Comp Immunol. 2019 Mar;92:291-298. doi: 10.1016/j.dci.2018.11.009. Epub 2018 Nov 17. PubMed PMID: 30458182.

8: Ogata Y, Nemoto W, Yamagata R, Nakagawasai O, Shimoyama S, Furukawa T, Ueno S, Tan-No K. Anti-hypersensitive effect of angiotensin (1-7) on streptozotocin-induced diabetic neuropathic pain in mice. Eur J Pain. 2019 Apr;23(4):739-749. doi: 10.1002/ejp.1341. Epub 2018 Dec 4. PubMed PMID: 30421564.

9: Yu XJ, Miao YW, Li HB, Su Q, Liu KL, Fu LY, Hou YK, Shi XL, Li Y, Mu JJ, Chen WS, Cui W, Zhu GQ, Ebenezer PJ, Francis J, Kang YM. Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension. Neurosci Bull. 2019 Feb;35(1):47-56. doi: 10.1007/s12264-018-0297-4. Epub 2018 Oct 16. PubMed PMID: 30328008; PubMed Central PMCID: PMC6357275.

10: Tao MX, Xue X, Gao L, Lu JL, Zhou JS, Jiang T, Zhang YD. Involvement of angiotensin-(1-7) in the neuroprotection of captopril against focal cerebral ischemia. Neurosci Lett. 2018 Nov 20;687:16-21. doi: 10.1016/j.neulet.2018.09.024. Epub 2018 Sep 13. PubMed PMID: 30219484.

11: Chen QF, Kuang XD, Yuan QF, Hao H, Zhang T, Huang YH, Zhou XY. Lipoxin A(4) attenuates LPS-induced acute lung injury via activation of the ACE2-Ang-(1-7)-Mas axis. Innate Immun. 2018 Jul;24(5):285-296. doi: 10.1177/1753425918785008. Epub 2018 Jul 3. PubMed PMID: 29969931.

12: Liu Z, Liu J, Xiao M, Wang J, Yao F, Zeng W, Yu L, Guan Y, Wei W, Peng Z, Zhu K, Wang J, Yang Z, Zhong J, Chen J. Mesenchymal stem cell-derived microvesicles alleviate pulmonary arterial hypertension by regulating renin-angiotensin system. J Am Soc Hypertens. 2018 Jun;12(6):470-478. doi: 10.1016/j.jash.2018.02.006. Epub 2018 Mar 15. PubMed PMID: 29752040.

13: Zhou Y, Li M, Zhu DL, Jiang T, Gao Q, Tang XH, Zhang SG, Lu J, Zhang YD. Neuroprotective effect of angiotensin-(1-7) against rotenone-induced oxidative damage in CATH.a neurons. Toxicol In Vitro. 2018 Aug;50:373-382. doi: 10.1016/j.tiv.2018.04.005. Epub 2018 Apr 14. PubMed PMID: 29665408.

14: Rabie MA, Abd El Fattah MA, Nassar NN, El-Abhar HS, Abdallah DM. Angiotensin 1-7 ameliorates 6-hydroxydopamine lesions in hemiparkinsonian rats through activation of MAS receptor/PI3K/Akt/BDNF pathway and inhibition of angiotensin II type-1 receptor/NF-κB axis. Biochem Pharmacol. 2018 May;151:126-134. doi: 10.1016/j.bcp.2018.01.047. Epub 2018 Feb 8. PubMed PMID: 29428223.

15: Kuczeriszka M, Kompanowska-Jezierska E, Sadowski J, Prieto MC, Navar LG. Modulating Role of Ang1-7 in Control of Blood Pressure and Renal Function in AngII-infused Hypertensive Rats. Am J Hypertens. 2018 Mar 10;31(4):504-511. doi: 10.1093/ajh/hpy006. PubMed PMID: 29329358; PubMed Central PMCID: PMC5861538.

16: Wang Y, Wang G, Cui L, Liu R, Xiao H, Yin C. Angiotensin 1-7 ameliorates caerulein-induced inflammation in pancreatic acinar cells by downregulating Toll-like receptor 4/nuclear factor-κB expression. Mol Med Rep. 2018 Mar;17(3):3511-3518. doi: 10.3892/mmr.2017.8354. Epub 2017 Dec 27. PubMed PMID: 29286117; PubMed Central PMCID: PMC5802148.

17: Yang YY, Sun XT, Li ZX, Chen WY, Wang X, Liang ML, Shi H, Yang ZS, Zeng WT. Protective effect of angiotensin-(1-7) against hyperglycaemia-induced injury in H9c2 cardiomyoblast cells via the PI3K̸Akt signaling pathway. Int J Mol Med. 2018 Mar;41(3):1283-1292. doi: 10.3892/ijmm.2017.3322. Epub 2017 Dec 15. Erratum in: Int J Mol Med. 2018 Aug;42(2):1199. PubMed PMID: 29286068; PubMed Central PMCID: PMC5819934.

18: Yu X, Cui L, Hou F, Liu X, Wang Y, Wen Y, Chi C, Li C, Liu R, Yin C. Angiotensin-converting enzyme 2-angiotensin (1-7)-Mas axis prevents pancreatic acinar cell inflammatory response via inhibition of the p38 mitogen-activated protein kinase/nuclear factor-κB pathway. Int J Mol Med. 2018 Jan;41(1):409-420. doi: 10.3892/ijmm.2017.3252. Epub 2017 Nov 13. PubMed PMID: 29138810.

19: Kopf PG, Park SK, Herrnreiter A, Krause C, Roques BP, Campbell WB. Obligatory Metabolism of Angiotensin II to Angiotensin III for Zona Glomerulosa Cell-Mediated Relaxations of Bovine Adrenal Cortical Arteries. Endocrinology. 2018 Jan 1;159(1):238-247. doi: 10.1210/en.2017-00759. PubMed PMID: 29088382; PubMed Central PMCID: PMC5761603.

20: Bilodeau MS, Leiter JC. Angiotensin 1-7 in the rostro-ventrolateral medulla increases blood pressure and splanchnic sympathetic nerve activity in anesthetized rats. Respir Physiol Neurobiol. 2018 Jan;247:103-111. doi: 10.1016/j.resp.2017.10.003. Epub 2017 Oct 6. PubMed PMID: 28993263.