C286

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565726

CAS#: N/A

Description: C286 is a biochemical.


Price and Availability

Size
Price

Size
Price

Size
Price

C286 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 565726
Name: C286
CAS#: N/A
Chemical Formula: C19H14N2O4
Exact Mass: 334.0954
Molecular Weight: 334.331
Elemental Analysis: C, 68.26; H, 4.22; N, 8.38; O, 19.14


Synonym: C286; C 286; C-286; RARß-Agonist-10; RARß Agonist 10;

IUPAC/Chemical Name: RARβ-Agonist-10; 4-(5-(4,7-Dimethylbenzofuran-2-yl)-1,2,4-oxadiazol-3-yl)benzoic acid

InChi Key: AVCXUODHLRZJJP-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H14N2O4/c1-10-3-4-11(2)16-14(10)9-15(24-16)18-20-17(21-25-18)12-5-7-13(8-6-12)19(22)23/h3-9H,1-2H3,(H,22,23)

SMILES Code: O=C(O)C1=CC=C(C2=NOC(C3=CC4=C(C)C=CC(C)=C4O3)=N2)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Samson M, Yang T, Omar M, Xu M, Zhang X, Alphonse U, Rao Z. Improved thermostability and catalytic efficiency of overexpressed catalase from B. pumilus ML 413 (KatX2) by introducing disulfide bond C286-C289. Enzyme Microb Technol. 2018 Dec;119:10-16. doi: 10.1016/j.enzmictec.2018.08.002. Epub 2018 Aug 9. PubMed PMID: 30243381.

2: Lee S, Wales TE, Escudero S, Cohen DT, Luccarelli J, Gallagher CG, Cohen NA, Huhn AJ, Bird GH, Engen JR, Walensky LD. Allosteric inhibition of antiapoptotic MCL-1. Nat Struct Mol Biol. 2016 Jun;23(6):600-7. doi: 10.1038/nsmb.3223. Epub 2016 May 9. PubMed PMID: 27159560; PubMed Central PMCID: PMC4900187.

3: Lee CY, Meighen EA. Cysteine-286 as the site of acylation of the Lux-specific fatty acyl-CoA reductase. Biochim Biophys Acta. 1997 Apr 4;1338(2):215-22. PubMed PMID: 9128139.

4: González-Segura L, Mújica-Jiménez C, Muñoz-Clares RA. Reaction of the catalytic cysteine of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa with arsenite-BAL and phenylarsine oxide. Chem Biol Interact. 2009 Mar 16;178(1-3):64-9. doi: 10.1016/j.cbi.2008.10.049. Epub 2008 Nov 5. PubMed PMID: 19028474.

5: Goncalves MB, Wu Y, Clarke E, Grist J, Hobbs C, Trigo D, Jack J, Corcoran JPT. Regulation of Myelination by Exosome Associated Retinoic Acid Release from NG2-Positive Cells. J Neurosci. 2019 Apr 17;39(16):3013-3027. doi: 10.1523/JNEUROSCI.2922-18.2019. Epub 2019 Feb 13. PubMed PMID: 30760627; PubMed Central PMCID: PMC6468108.

6: Pang YP. Novel acetylcholinesterase target site for malaria mosquito control. PLoS One. 2006 Dec 20;1:e58. PubMed PMID: 17183688; PubMed Central PMCID: PMC1762403.

7: González-Segura L, Rudiño-Piñera E, Muñoz-Clares RA, Horjales E. The crystal structure of a ternary complex of betaine aldehyde dehydrogenase from Pseudomonas aeruginosa Provides new insight into the reaction mechanism and shows a novel binding mode of the 2'-phosphate of NADP+ and a novel cation binding site. J Mol Biol. 2009 Jan 16;385(2):542-57. doi: 10.1016/j.jmb.2008.10.082. Epub 2008 Nov 5. PubMed PMID: 19013472.

8: Zhao Z, Pompey S, Dong H, Weng J, Garuti R, Michaely P. S-nitrosylation of ARH is required for LDL uptake by the LDL receptor. J Lipid Res. 2013 Jun;54(6):1550-9. doi: 10.1194/jlr.M033167. Epub 2013 Apr 7. PubMed PMID: 23564733; PubMed Central PMCID: PMC3646456.

9: Yan Y, Calikoglu AS, Jain N. Vitamin D-dependent rickets type 1: a rare, but treatable, cause of severe hypotonia in infancy. J Child Neurol. 2011 Dec;26(12):1571-5. doi: 10.1177/0883073811411190. Epub 2011 Jun 23. PubMed PMID: 21700898.

10: Goncalves MB, Clarke E, Jarvis CI, Barret Kalindjian S, Pitcher T, Grist J, Hobbs C, Carlstedt T, Jack J, Brown JT, Mills M, Mumford P, Borthwick AD, Corcoran JPT. Discovery and lead optimisation of a potent, selective and orally bioavailable RARβ agonist for the potential treatment of nerve injury. Bioorg Med Chem Lett. 2019 Apr 15;29(8):995-1000. doi: 10.1016/j.bmcl.2019.02.011. Epub 2019 Feb 11. Erratum in: Bioorg Med Chem Lett. 2019 Jun 14;:. PubMed PMID: 30792038; PubMed Central PMCID: PMC6419571.

11: Schulteis CT, John SA, Huang Y, Tang CY, Papazian DM. Conserved cysteine residues in the shaker K+ channel are not linked by a disulfide bond. Biochemistry. 1995 Feb 7;34(5):1725-33. PubMed PMID: 7849032.

12: Li Y, Li Z, Li Y, Ye J. Identification of Th cell epitopes on clfA adhesin of Staphylococcus aureus and characterization of their role in immunity. Wei Sheng Wu Xue Bao. 2013 Sep 4;53(9):966-75. PubMed PMID: 24377249.

13: Moreira PR, Duez C, Dehareng D, Antunes A, Almeida-Vara E, Frère JM, Malcata FX, Duarte JC. Molecular characterisation of a versatile peroxidase from a Bjerkandera strain. J Biotechnol. 2005 Sep 10;118(4):339-52. PubMed PMID: 16026883.

14: Velasco-García R, Zaldívar-Machorro VJ, Mújica-Jiménez C, González-Segura L, Muñoz-Clares RA. Disulfiram irreversibly aggregates betaine aldehyde dehydrogenase--a potential target for antimicrobial agents against Pseudomonas aeruginosa. Biochem Biophys Res Commun. 2006 Mar 10;341(2):408-15. Epub 2006 Jan 11. PubMed PMID: 16426571.

15: Schrader AM, Camden JM, Weisman GA. P2Y2 nucleotide receptor up-regulation in submandibular gland cells from the NOD.B10 mouse model of Sjögren's syndrome. Arch Oral Biol. 2005 Jun;50(6):533-40. Epub 2004 Dec 15. PubMed PMID: 15848146.

16: Emerich DF, Granholm L. RECENT ADVANCES IN NEURAL TRANSPLANT RESEARCH. Cell Transplant. 1998 Mar 1;7(2):83-85. doi: 10.1177/096368979800700203. PubMed PMID: 28234070.

17: Feng W, Williams T. Cloning and characterization of the mouse AP-2 epsilon gene: a novel family member expressed in the developing olfactory bulb. Mol Cell Neurosci. 2003 Oct;24(2):460-75. PubMed PMID: 14572467.

18: Siddiqi R, Khan MA. Amino acid requirement of six strains of Listeria monocytogenes. Zentralbl Bakteriol. 1989 Jul;271(2):146-52. PubMed PMID: 2505787.

19: Henry S, Pfenninger KH, Mott JL, Granholm AC. Anatomical distribution of glycoprotein 93 (gp93) on nerve fibers during rat brain development. Cell Tissue Res. 1999 Jul;297(1):67-79. PubMed PMID: 10398884.