BAI2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565687

CAS#: 335166-36-4

Description: Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. It is a member of the adhesion-GPCR family of receptors. BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.

Chemical Structure

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BAI2
CAS# 335166-36-4
Instruction

Theoretical Analysis

MedKoo Cat#: 565687
Name: BAI2
CAS#: 335166-36-4
Chemical Formula: C19H20Br2FN3
Exact Mass: 467.00
Molecular Weight: 469.196
Elemental Analysis: C, 48.64; H, 4.30; Br, 34.06; F, 4.05; N, 8.96

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: BAI2; BAI 2; BAI-2; Brain-specific angiogenesis inhibitor 2

IUPAC/Chemical Name: 3,6-Dibromo-9-(2-fluoro-3-(piperazin-1-yl)propyl)-9H-carbazole

InChi Key: BSTYITXHUQTYBA-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20Br2FN3/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)25(18)12-15(22)11-24-7-5-23-6-8-24/h1-4,9-10,15,23H,5-8,11-12H2

SMILES Code: FC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 469.20 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Speca DJ, Trimmer JS, Peterson AS, Díaz E. Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Mamm Genome. 2017 Dec;28(11-12):465-475. doi: 10.1007/s00335-017-9716-5. Epub 2017 Sep 12. PubMed PMID: 28894906; PubMed Central PMCID: PMC5702255.

2: Purcell RH, Toro C, Gahl WA, Hall RA. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. Hum Mutat. 2017 Dec;38(12):1751-1760. doi: 10.1002/humu.23336. Epub 2017 Sep 20. PubMed PMID: 28891236; PubMed Central PMCID: PMC5679302.

3: Zencir S, Ovee M, Dobson MJ, Banerjee M, Topcu Z, Mohanty S. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. Biochem Biophys Res Commun. 2011 Aug 12;411(4):792-7. doi: 10.1016/j.bbrc.2011.07.029. Epub 2011 Jul 20. PubMed PMID: 21787750; PubMed Central PMCID: PMC3157015.

4: Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Hum Genet. 2010 Oct;128(4):433-41. doi: 10.1007/s00439-010-0862-z. Epub 2010 Jul 31. PubMed PMID: 20677014.

5: Okajima D, Kudo G, Yokota H. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. J Recept Signal Transduct Res. 2010 Jun;30(3):143-53. doi: 10.3109/10799891003671139. PubMed PMID: 20367554.

6: Jeong BC, Kim MY, Lee JH, Kee HJ, Kho DH, Han KE, Qian YR, Kim JK, Kim KK. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. FEBS Lett. 2006 Jan 23;580(2):669-76. Epub 2006 Jan 6. PubMed PMID: 16412436.

7: Kee HJ, Koh JT, Kim MY, Ahn KY, Kim JK, Bae CS, Park SS, Kim KK. Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab. 2002 Sep;22(9):1054-67. PubMed PMID: 12218411.