BAI2

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565687

CAS#: 335166-36-4

Description: Brain-specific angiogenesis inhibitor 2 is a protein that in humans is encoded by the BAI2 gene. It is a member of the adhesion-GPCR family of receptors. BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.


Price and Availability

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BAI2 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565687
Name: BAI2
CAS#: 335166-36-4
Chemical Formula: C19H20Br2FN3
Exact Mass: 467.0008
Molecular Weight: 469.1964
Elemental Analysis: C, 48.64; H, 4.30; Br, 34.06; F, 4.05; N, 8.96


Synonym: BAI2; BAI 2; BAI-2; Brain-specific angiogenesis inhibitor 2

IUPAC/Chemical Name: 3,6-Dibromo-9-(2-fluoro-3-(piperazin-1-yl)propyl)-9H-carbazole

InChi Key: BSTYITXHUQTYBA-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H20Br2FN3/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)25(18)12-15(22)11-24-7-5-23-6-8-24/h1-4,9-10,15,23H,5-8,11-12H2

SMILES Code: FC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Speca DJ, Trimmer JS, Peterson AS, Díaz E. Whole exome sequencing reveals a functional mutation in the GAIN domain of the Bai2 receptor underlying a forward mutagenesis hyperactivity QTL. Mamm Genome. 2017 Dec;28(11-12):465-475. doi: 10.1007/s00335-017-9716-5. Epub 2017 Sep 12. PubMed PMID: 28894906; PubMed Central PMCID: PMC5702255.

2: Purcell RH, Toro C, Gahl WA, Hall RA. A disease-associated mutation in the adhesion GPCR BAI2 (ADGRB2) increases receptor signaling activity. Hum Mutat. 2017 Dec;38(12):1751-1760. doi: 10.1002/humu.23336. Epub 2017 Sep 20. PubMed PMID: 28891236; PubMed Central PMCID: PMC5679302.

3: Zencir S, Ovee M, Dobson MJ, Banerjee M, Topcu Z, Mohanty S. Identification of brain-specific angiogenesis inhibitor 2 as an interaction partner of glutaminase interacting protein. Biochem Biophys Res Commun. 2011 Aug 12;411(4):792-7. doi: 10.1016/j.bbrc.2011.07.029. Epub 2011 Jul 20. PubMed PMID: 21787750; PubMed Central PMCID: PMC3157015.

4: Shimada M, Miyagawa T, Kawashima M, Tanaka S, Honda Y, Honda M, Tokunaga K. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. Hum Genet. 2010 Oct;128(4):433-41. doi: 10.1007/s00439-010-0862-z. Epub 2010 Jul 31. PubMed PMID: 20677014.

5: Okajima D, Kudo G, Yokota H. Brain-specific angiogenesis inhibitor 2 (BAI2) may be activated by proteolytic processing. J Recept Signal Transduct Res. 2010 Jun;30(3):143-53. doi: 10.3109/10799891003671139. PubMed PMID: 20367554.

6: Jeong BC, Kim MY, Lee JH, Kee HJ, Kho DH, Han KE, Qian YR, Kim JK, Kim KK. Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor. FEBS Lett. 2006 Jan 23;580(2):669-76. Epub 2006 Jan 6. PubMed PMID: 16412436.

7: Kee HJ, Koh JT, Kim MY, Ahn KY, Kim JK, Bae CS, Park SS, Kim KK. Expression of brain-specific angiogenesis inhibitor 2 (BAI2) in normal and ischemic brain: involvement of BAI2 in the ischemia-induced brain angiogenesis. J Cereb Blood Flow Metab. 2002 Sep;22(9):1054-67. PubMed PMID: 12218411.