BAI1 inhibitor
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565686

CAS#: 335165-68-9

Description: Brain-specific angiogenesis inhibitor 1 is a protein that in humans is encoded by the BAI1 gene. It is a member of the adhesion-GPCR family of receptors.


Price and Availability

Size
Price

1g
USD 3450
Size
Price

2g
USD 5750
Size
Price

5g
USD 12950

BAI1, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565686
Name: BAI1 inhibitor
CAS#: 335165-68-9
Chemical Formula: C19H21Br2N3O
Exact Mass: 465.0051
Molecular Weight: 467.205
Elemental Analysis: C, 48.85; H, 4.53; Br, 34.21; N, 8.99; O, 3.42


Synonym: BAI1; BAI 1; BAI-1; Brain-specific angiogenesis inhibitor 1

IUPAC/Chemical Name: 1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(piperazin-1-yl)propan-2-ol

InChi Key: KUUJEXLRLIPQQJ-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H21Br2N3O/c20-13-1-3-18-16(9-13)17-10-14(21)2-4-19(17)24(18)12-15(25)11-23-7-5-22-6-8-23/h1-4,9-10,15,22,25H,5-8,11-12H2

SMILES Code: OC(CN1CCNCC1)CN2C3=C(C4=C2C=CC(Br)=C4)C=C(Br)C=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

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2: Hsiao CC, van der Poel M, van Ham TJ, Hamann J. Macrophages Do Not Express the Phagocytic Receptor BAI1/ADGRB1. Front Immunol. 2019 May 3;10:962. doi: 10.3389/fimmu.2019.00962. eCollection 2019. PubMed PMID: 31130954; PubMed Central PMCID: PMC6509540.

3: Chen J, Huang Y, Hui Q, Mathur R, Gwinn M, So-Armah K, Freiberg MS, Justice AC, Xu K, Marconi VC, Sun YV. Epigenetic Associations with Estimated Glomerular Filtration Rate (eGFR) among Men with HIV Infection. Clin Infect Dis. 2019 Mar 20. pii: ciz240. doi: 10.1093/cid/ciz240. [Epub ahead of print] PubMed PMID: 30893429.

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5: Zeng Z, Huo X, Zhang Y, Hylkema MN, Wu Y, Xu X. Differential DNA methylation in newborns with maternal exposure to heavy metals from an e-waste recycling area. Environ Res. 2019 Apr;171:536-545. doi: 10.1016/j.envres.2019.01.007. Epub 2019 Jan 6. PubMed PMID: 30763874.

6: Weng Z, Situ C, Lin L, Wu Z, Zhu J, Zhang R. Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nat Commun. 2019 Jan 3;10(1):51. doi: 10.1038/s41467-018-07938-9. PubMed PMID: 30604775; PubMed Central PMCID: PMC6318265.

7: Moon SY, Shin SA, Oh YS, Park HH, Lee CS. Understanding the Role of the BAI Subfamily of Adhesion G Protein-Coupled Receptors (GPCRs) in Pathological and Physiological Conditions. Genes (Basel). 2018 Nov 30;9(12). pii: E597. doi: 10.3390/genes9120597. Review. PubMed PMID: 30513696; PubMed Central PMCID: PMC6316137.

8: Tu YK, Duman JG, Tolias KF. The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling. J Neurosci. 2018 Sep 26;38(39):8388-8406. doi: 10.1523/JNEUROSCI.3461-17.2018. Epub 2018 Aug 17. PubMed PMID: 30120207; PubMed Central PMCID: PMC6158688.

9: Choi JS, Bae WY, Nam S, Jeong JW. New Targets for Parkinson's Disease: Adhesion G Protein-Coupled Receptor B1 is Downregulated by AMP-Activated Protein Kinase Activation. OMICS. 2018 Jul;22(7):493-501. doi: 10.1089/omi.2018.0047. PubMed PMID: 30004846.

10: Zhu D, Osuka S, Zhang Z, Reichert ZR, Yang L, Kanemura Y, Jiang Y, You S, Zhang H, Devi NS, Bhattacharya D, Takano S, Gillespie GY, Macdonald T, Tan C, Nishikawa R, Nelson WG, Olson JJ, Van Meir EG. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation. Cancer Cell. 2018 Jun 11;33(6):1004-1016.e5. doi: 10.1016/j.ccell.2018.05.006. PubMed PMID: 29894688; PubMed Central PMCID: PMC6002773.

11: Gęgotek A, Domingues P, Wroński A, Wójcik P, Skrzydlewska E. Proteomic plasma profile of psoriatic patients. J Pharm Biomed Anal. 2018 Jun 5;155:185-193. doi: 10.1016/j.jpba.2018.03.068. Epub 2018 Apr 4. PubMed PMID: 29635173.

12: Bai WJ, Wang X. Appreciation of symmetry in natural product synthesis. Nat Prod Rep. 2017 Dec 13;34(12):1345-1358. doi: 10.1039/c7np00045f. Review. PubMed PMID: 29168875.

13: Penberthy KK, Rival C, Shankman LS, Raymond MH, Zhang J, Perry JSA, Lee CS, Han CZ, Onengut-Gumuscu S, Palczewski K, Lysiak JJ, Ravichandran KS. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017 Nov 7;7(1):14623. doi: 10.1038/s41598-017-15191-1. PubMed PMID: 29116131; PubMed Central PMCID: PMC5676788.

14: Zhang W, He H, Zang M, Wu Q, Zhao H, Lu LL, Ma P, Zheng H, Wang N, Zhang Y, He S, Chen X, Wu Z, Wang X, Cai J, Liu Z, Sun Z, Zeng YX, Qu C, Jiao Y. Genetic Features of Aflatoxin-Associated Hepatocellular Carcinoma. Gastroenterology. 2017 Jul;153(1):249-262.e2. doi: 10.1053/j.gastro.2017.03.024. Epub 2017 Mar 29. PubMed PMID: 28363643.

15: Mathema VB, Na-Bangchang K. Regulatory roles of brain-specific angiogenesis inhibitor 1(BAI1) protein in inflammation, tumorigenesis and phagocytosis: A brief review. Crit Rev Oncol Hematol. 2017 Mar;111:81-86. doi: 10.1016/j.critrevonc.2017.01.006. Epub 2017 Jan 16. Review. PubMed PMID: 28259299.

16: Bolyard C, Meisen WH, Banasavadi-Siddegowda Y, Hardcastle J, Yoo JY, Wohleb ES, Wojton J, Yu JG, Dubin S, Khosla M, Xu B, Smith J, Alvarez-Breckenridge C, Pow-Anpongkul P, Pichiorri F, Zhang J, Old M, Zhu D, Van Meir EG, Godbout JP, Caligiuri MA, Yu J, Kaur B. BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy. Clin Cancer Res. 2017 Apr 1;23(7):1809-1819. doi: 10.1158/1078-0432.CCR-16-1818. Epub 2016 Nov 9. PubMed PMID: 27852701; PubMed Central PMCID: PMC5380537.

17: Hamann J, Hsiao CC, Lee CS, Ravichandran KS, Lin HH. Adhesion GPCRs as Modulators of Immune Cell Function. Handb Exp Pharmacol. 2016;234:329-350. Review. PubMed PMID: 27832495.

18: Fan W, Chang S, Shan X, Gao D, Zhang SQ, Zhang J, Jiang N, Ma D, Mao Z. Transcriptional profile of SH-SY5Y human neuroblastoma cells transfected by Toxoplasma rhoptry protein 16. Mol Med Rep. 2016 Nov;14(5):4099-4108. doi: 10.3892/mmr.2016.5758. Epub 2016 Sep 21. PubMed PMID: 27666388; PubMed Central PMCID: PMC5101894.

19: Tian DW, Hu HL, Sun Y, Tang Y, Lei MD, Liu LW, Han RF, Wu CL. Biological effects of eukaryotic recombinant plasmid pReceiver-M61-BAI-1 transfection on T24 cells and HUVECs. Mol Med Rep. 2016 Aug;14(2):1553-9. doi: 10.3892/mmr.2016.5422. Epub 2016 Jun 23. PubMed PMID: 27356780; PubMed Central PMCID: PMC4940095.

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