WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565643
Description: JH-T4 is a novel sirt2 inhibitor, increasing intracellular k-ras4a lysine fatty acylation
MedKoo Cat#: 565643
Chemical Formula: C34H51N3O4S
Exact Mass: 597.36
Molecular Weight: 597.859
Elemental Analysis: C, 68.31; H, 8.60; N, 7.03; O, 10.70; S, 5.36
This product is not in stock, which may be available by custom synthesis.
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Synonym: JH-T4; JH T4; JHT4
IUPAC/Chemical Name: Benzyl (S)-(1-((3-hydroxyphenyl)amino)-1-oxo-6-tetradecanethioamidohexan-2-yl)carbamate
InChi Key: HHDDBQCFKUYHIS-HKBQPEDESA-N
InChi Code: InChI=1S/C34H51N3O4S/c1-2-3-4-5-6-7-8-9-10-11-15-24-32(42)35-25-17-16-23-31(33(39)36-29-21-18-22-30(38)26-29)37-34(40)41-27-28-19-13-12-14-20-28/h12-14,18-22,26,31,38H,2-11,15-17,23-25,27H2,1H3,(H,35,42)(H,36,39)(H,37,40)/t31-/m0/s1
SMILES Code: O=C(OCC1=CC=CC=C1)N[C@@H](CCCCNC(CCCCCCCCCCCCC)=S)C(NC2=CC=CC(O)=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 597.859 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Spiegelman NA, Hong JY, Hu J, Jing H, Wang M, Price IR, Cao J, Yang M, Zhang X, Lin H. A Small-Molecule SIRT2 Inhibitor That Promotes K-Ras4a Lysine Fatty-Acylation. ChemMedChem. 2019 Apr 3;14(7):744-748. doi: 10.1002/cmdc.201800715. Epub 2019 Feb 25. PubMed PMID: 30734528; PubMed Central PMCID: PMC6452895.