WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565636


Description: F-B1 is a novel inhibitor of bcr/abl, inducing apoptosis in chronic myelogenous leukemia cells

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 565636
Name: F-B1
Chemical Formula: C19H22O5
Exact Mass: 330.1467
Molecular Weight: 330.38
Elemental Analysis: C, 69.07; H, 6.71; O, 24.21

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: F-B1; F B1; FB1

IUPAC/Chemical Name: 2-(2-Hydroxy-5-methylhex-4-en-2-yl)-7-methoxy-2,3-dihydro-4H-furo[3,2-c]chromen-4-one


InChi Code: InChI=1S/C19H22O5/c1-11(2)7-8-19(3,21)16-10-14-17(24-16)13-6-5-12(22-4)9-15(13)23-18(14)20/h5-7,9,16,21H,8,10H2,1-4H3

SMILES Code: O=C1C2=C(OC(C(C/C=C(C)/C)(O)C)C2)C3=C(O1)C=C(OC)C=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 330.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

1: Liang H, Liu G, Lu S, Chen S, Jiang D, Shi H, Fei Q. Epidemiology of ossification of the spinal ligaments and associated factors in the Chinese population: a cross-sectional study of 2000 consecutive individuals. BMC Musculoskelet Disord. 2019 May 25;20(1):253. doi: 10.1186/s12891-019-2569-1. PubMed PMID: 31128588; PubMed Central PMCID: PMC6534908.

2: Wang F, Wang J, Chong Z, Mu Y. A modified DAW-22 compound F-B1 inhibits Bcr/Abl and induces apoptosis in chronic myelogenous leukemia cells. Anticancer Drugs. 2019 Feb;30(2):159-166. doi: 10.1097/CAD.0000000000000712. PubMed PMID: 30422832.

3: Godet C. Entropy effects in the collective dynamic behavior of alkyl monolayers tethered to Si(111). Beilstein J Nanotechnol. 2015 Feb 26;6:583-94. doi: 10.3762/bjnano.6.60. eCollection 2015. PubMed PMID: 25821699; PubMed Central PMCID: PMC4362335.

4: Ladhe KA, Sastri MR, Madaan JB, Vakil KK. Effect of remineralizing agents on bond strength of orthodontic brackets: an in vitro study. Prog Orthod. 2014 Apr 16;15(1):28. doi: 10.1186/s40510-014-0028-y. PubMed PMID: 24935482; PubMed Central PMCID: PMC4047489.

5: Gong L, Yang B, Xu M, Cheng B, Tang X, Zheng P, Jing Y, Wu GJ. Bortezomib-induced apoptosis in cultured pancreatic cancer cells is associated with ceramide production. Cancer Chemother Pharmacol. 2014 Jan;73(1):69-77. doi: 10.1007/s00280-013-2318-3. Epub 2013 Nov 5. PubMed PMID: 24190701.

6: Al-Taher F, Banaszewski K, Jackson L, Zweigenbaum J, Ryu D, Cappozzo J. Rapid method for the determination of multiple mycotoxins in wines and beers by LC-MS/MS using a stable isotope dilution assay. J Agric Food Chem. 2013 Mar 13;61(10):2378-84. doi: 10.1021/jf304729f. Epub 2013 Jan 22. PubMed PMID: 23256627.

7: Zhang S, Wang X, He Y, Ding R, Liu H, Xu J, Feng M, Li G, Wang M, Peng C, Qi C. (18)F Labeled benzimidazole derivatives as potential radiotracer for positron emission tomography (PET) tumor imaging. Bioorg Med Chem. 2010 Apr 1;18(7):2394-401. doi: 10.1016/j.bmc.2010.02.060. Epub 2010 Mar 6. PubMed PMID: 20303769.

8: Herrera P, Arcos-Burgos M, Valenzuela CY, Pandey JP. Gm and Km allotypes and typhoid fever. Exp Clin Immunogenet. 1996;13(3-4):121-5. PubMed PMID: 9165265.

9: Yang CL, Du XH, Wu H. Inhibitory effects of high molecular weight substances from CAPD dialysate on mouse bone marrow progenitor cells and lymphocyte transformation. Chin Med J (Engl). 1994 Apr;107(4):248-53. PubMed PMID: 8088189.

10: Canese R, Podo F. [Localized nuclear magnetic resonance spectroscopy in vivo. Physical principles and quantitative problems]. Ann Ist Super Sanita. 1991;27(4):675-708. Review. Italian. PubMed PMID: 1820740.