AM-92016 HCl | CAS# 133229-11-5

AM-92016 HCl
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555585

CAS#: 133229-11-5 (HCl)

Description: AM-92016 is an oxypropanolamine analogue of sotalol, has been shown to possess Class III anti-arrhythmic properties in-vitro at concentrations showing 1000 times more potency than sotalol. AM 92016 exhibited proarrhythmic rather than antiarrhythmic activity when administered in-vivo to either guinea-pigs or pigs.

Chemical Structure

AM-92016 HCl

CAS# 133229-11-5 (HCl)

Instruction

Theoretical Analysis

MedKoo Cat#: 555585
Name: AM-92016 HCl
CAS#: 133229-11-5 (HCl)
Chemical Formula: C19H25Cl3N2O4S
Exact Mass: 0.00
Molecular Weight: 483.829
Elemental Analysis: C, 47.17; H, 5.21; Cl, 21.98; N, 5.79; O, 13.23; S, 6.63

Price and Availability

Size	Price	Availability	Quantity
25mg	USD 250
50mg	USD 450
100mg	USD 750
200mg	USD 1250
500mg	USD 1950
1g	USD 3250
2g	USD 5850
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 133229-23-9 (free base) 133229-11-5 (HCl)

Synonym: AM-92016 HCl; AM 92016 HCl; AM92016 HCl; AM-92016 hydrochloride

IUPAC/Chemical Name: N-(4-(3-((3,4-dichlorophenethyl)(methyl)amino)-2-hydroxypropoxy)phenyl)methanesulfonamide hydrochloride

InChi Key: TXOARFPCQOBODS-UHFFFAOYSA-N

InChi Code: InChI=1S/C19H24Cl2N2O4S.ClH/c1-23(10-9-14-3-8-18(20)19(21)11-14)12-16(24)13-27-17-6-4-15(5-7-17)22-28(2,25)26;/h3-8,11,16,22,24H,9-10,12-13H2,1-2H3;1H

SMILES Code: OC(CN(C)CCC1=CC=C(Cl)C(Cl)=C1)COC2=CC=C(NS(=O)(C)=O)C=C2.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 483.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Katsuki H, Shinohara A, Fujimoto S, Kume T, Akaike A. Tetraethylammonium
exacerbates ischemic neuronal injury in rat cerebrocortical slice cultures. Eur J
Pharmacol. 2005 Jan 31;508(1-3):85-91. Epub 2005 Jan 6. PubMed PMID: 15680257.

2: Hagerty MJ, Wainwright CL, Kane KA. The in-vivo cardiovascular effects of a
putative class III anti-arrhythmic drug, AM 92016. J Pharm Pharmacol. 1996
Apr;48(4):417-21. PubMed PMID: 8794994.

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