Ibr-7

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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565606

CAS#: N/A

Description: Ibr-7 is a novel btk inhibitor, inhibiting non-small cell lung cancer (nsclc) via targeting mtorc1/s6

Price and Availability

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Pricing updated 2020-10-29. Prices are subject to change without notice.

Ibr-7 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure

Theoretical Analysis

MedKoo Cat#: 565606
Name: Ibr-7
CAS#: N/A
Chemical Formula: C24H22BrN7O2
Exact Mass: 519.1018
Molecular Weight: 520.391
Elemental Analysis: C, 55.39; H, 4.26; Br, 15.35; N, 18.84; O, 6.15

Synonym: Ibr-7; Ibr 7; Ibr7

IUPAC/Chemical Name: (R)-1-(3-(4-Amino-3-(5-phenoxypyridin-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)-2-bromoprop-2-en-1-one

InChi Key: IJNQTKBEQIQXHA-MRXNPFEDSA-N

InChi Code: InChI=1S/C24H22BrN7O2/c1-15(25)24(33)31-11-5-6-16(13-31)32-23-20(22(26)28-14-29-23)21(30-32)19-10-9-18(12-27-19)34-17-7-3-2-4-8-17/h2-4,7-10,12,14,16H,1,5-6,11,13H2,(H2,26,28,29)/t16-/m1/s1

SMILES Code: C=C(Br)C(N1C[C@H](N2N=C(C3=NC=C(OC4=CC=CC=C4)C=C3)C5=C(N)N=CN=C52)CCC1)=O

Technical Data

Appearance:

Solid powder

Purity:

>98% (or refer to the Certificate of Analysis)

Shipping Condition:

Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:

Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:

Soluble in DMSO

Shelf Life:

>3 years if stored properly

Drug Formulation:

This drug may be formulated in DMSO

Stock Solution Storage:

0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:

2934.99.9001

References

1: Zhang B, Wang L, Zhang Q, Yan Y, Jiang H, Hu R, Zhou X, Liu X, Feng J, Lin N. The Ibr-7 derivative of ibrutinib exhibits enhanced cytotoxicity against non-small cell lung cancer cells via targeting of mTORC1/S6 signaling. Mol Oncol. 2019 Apr;13(4):946-958. doi: 10.1002/1878-0261.12454. Epub 2019 Feb 22. PubMed PMID: 30663221; PubMed Central PMCID: PMC6441926.

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