WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565591
Description: BAA485 is a novel activator of pyrin inflammasome
MedKoo Cat#: 565591
Chemical Formula: C24H38O4
Exact Mass: 390.277
Molecular Weight: 390.564
Elemental Analysis: C, 73.81; H, 9.81; O, 16.39
This product is not in stock, which may be available by custom synthesis.
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Synonym: BAA485; BAA 485; BAA-485; BAA485; 12-Oxolithocholic acid; 12-Ketolithocholic acid;
IUPAC/Chemical Name: (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid
InChi Key: CVNYHSDFZXHMMJ-VPUMZWJWSA-N
InChi Code: InChI=1S/C24H38O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-20,25H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,23+,24-/m1/s1
SMILES Code: C[C@@H]([C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O)CCC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 390.564 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Falcone EL, Bryant C. Let's get this pyrin started! J Biol Chem. 2019 Mar 8;294(10):3367-3368. doi: 10.1074/jbc.H119.007830. Review. PubMed PMID: 30850508; PubMed Central PMCID: PMC6416431.
2: Alimov I, Menon S, Cochran N, Maher R, Wang Q, Alford J, Concannon JB, Yang Z, Harrington E, Llamas L, Lindeman A, Hoffman G, Schuhmann T, Russ C, Reece-Hoyes J, Canham SM, Cai X. Bile acid analogues are activators of pyrin inflammasome. J Biol Chem. 2019 Mar 8;294(10):3359-3366. doi: 10.1074/jbc.RA118.005103. Epub 2019 Jan 15. PubMed PMID: 30647128; PubMed Central PMCID: PMC6416436.