BAA485

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565591

CAS#: 5130-29-0

Description: BAA485 is a novel activator of pyrin inflammasome


Price and Availability

Size
Price

Size
Price

Size
Price

BAA485 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 565591
Name: BAA485
CAS#: 5130-29-0
Chemical Formula: C24H38O4
Exact Mass: 390.277
Molecular Weight: 390.564
Elemental Analysis: C, 73.81; H, 9.81; O, 16.39


Synonym: BAA485; BAA 485; BAA-485; BAA485; 12-Oxolithocholic acid; 12-Ketolithocholic acid;

IUPAC/Chemical Name: (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-12-oxohexadecahydro-1H-cyclopenta[a]phenanthren-17-yl)pentanoic acid

InChi Key: CVNYHSDFZXHMMJ-VPUMZWJWSA-N

InChi Code: InChI=1S/C24H38O4/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3/h14-20,25H,4-13H2,1-3H3,(H,27,28)/t14-,15-,16-,17+,18-,19+,20+,23+,24-/m1/s1

SMILES Code: C[C@@H]([C@H]([C@]12C)CC[C@@]1([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC2=O)CCC(O)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Falcone EL, Bryant C. Let's get this pyrin started! J Biol Chem. 2019 Mar 8;294(10):3367-3368. doi: 10.1074/jbc.H119.007830. Review. PubMed PMID: 30850508; PubMed Central PMCID: PMC6416431.

2: Alimov I, Menon S, Cochran N, Maher R, Wang Q, Alford J, Concannon JB, Yang Z, Harrington E, Llamas L, Lindeman A, Hoffman G, Schuhmann T, Russ C, Reece-Hoyes J, Canham SM, Cai X. Bile acid analogues are activators of pyrin inflammasome. J Biol Chem. 2019 Mar 8;294(10):3359-3366. doi: 10.1074/jbc.RA118.005103. Epub 2019 Jan 15. PubMed PMID: 30647128; PubMed Central PMCID: PMC6416436.