GI-530159 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565589

CAS#: Unknown

Description: GI-530159 is a selective dual trek1 and trek2 channel activator

Chemical Structure

GI-530159 HCl
CAS# Unknown

Theoretical Analysis

MedKoo Cat#: 565589
Name: GI-530159 HCl
CAS#: Unknown
Chemical Formula: C27H24Cl4F6N2O2
Exact Mass: 518.14
Molecular Weight: 664.291
Elemental Analysis: Chemical Formula: C27H24Cl4F6N2O2 Exact Mass: 662.0496 Molecular Weight: 664.2914 Elemental Analysis: C, 48.82; H, 3.64; Cl, 21.35; F, 17.16; N, 4.22; O, 4.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales or click below button.
Note: Price will be listed if it is available in the future.

Related CAS #: 69563-88-8,

Synonym: GI-530159; GI 530159; GI530159; GI-530159 HCl; GI-530159 hydrochloride; GI-530159 tetrahydrochloride

IUPAC/Chemical Name: 4,4'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis[benzenamine] tetrahydrochloride


InChi Code: InChI=1S/C27H20F6N2O2.4ClH/c28-26(29,30)25(27(31,32)33,17-1-9-21(10-2-17)36-23-13-5-19(34)6-14-23)18-3-11-22(12-4-18)37-24-15-7-20(35)8-16-24;;;;/h1-16H,34-35H2;4*1H

SMILES Code: FC(C(C1=CC=C(OC2=CC=C(N)C=C2)C=C1)(C3=CC=C(OC4=CC=C(N)C=C4)C=C3)C(F)(F)F)(F)F.[H]Cl.[H]Cl.[H]Cl.[H]Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Preparing Stock Solutions

The following data is based on the product molecular weight 664.291400000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Loucif AJC, Saintot PP, Liu J, Antonio BM, Zellmer SG, Yoger K, Veale EL, Wilbrey A, Omoto K, Cao L, Gutteridge A, Castle NA, Stevens EB, Mathie A. GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K(2P) ) channel opener, reduces rat dorsal root ganglion neuron excitability. Br J Pharmacol. 2018 Jun;175(12):2272-2283. doi: 10.1111/bph.14098. Epub 2017 Dec 29. PubMed PMID: 29150838; PubMed Central PMCID: PMC5980259.