BTZ

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MedKoo CAT#: 565478

CAS#: N/A

Description: BTZ is a novel covalent probe of recombinant and endogenous bromodomain-containing proteins, targeting a conserved lysine and a tyrosine residue in the variable za or bc loops


Price and Availability

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Pricing updated 2020-04-07. Prices are subject to change without notice.

BTZ is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565478
Name: BTZ
CAS#: N/A
Chemical Formula: C21H17Cl2N9O2
Exact Mass: 497.0882
Molecular Weight: 498.328
Elemental Analysis: C, 50.62; H, 3.44; Cl, 14.23; N, 25.30; O, 6.42


Synonym: BTZ

IUPAC/Chemical Name: But-3-yn-1-yl (6-(3-((4,6-dichloro-1,3,5-triazin-2-yl)amino)-4-methylphenyl)-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-yl)carbamate

InChi Key: ALHDRILUIXYPIB-UHFFFAOYSA-N

InChi Code: InChI=1S/C21H17Cl2N9O2/c1-4-5-8-34-21(33)25-16-10-15(31-32-12(3)29-30-17(16)32)13-7-6-11(2)14(9-13)24-20-27-18(22)26-19(23)28-20/h1,6-7,9-10H,5,8H2,2-3H3,(H,25,33)(H,24,26,27,28)

SMILES Code: O=C(OCCC#C)NC1=CC(C2=CC=C(C)C(NC3=NC(Cl)=NC(Cl)=N3)=C2)=NN4C1=NN=C4C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

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11: Huang FI, Wu YW, Sung TY, Liou JP, Lin MH, Pan SL, Yang CR. MPT0G413, A Novel HDAC6-Selective Inhibitor, and Bortezomib Synergistically Exert Anti-tumor Activity in Multiple Myeloma Cells. Front Oncol. 2019 Apr 9;9:249. doi: 10.3389/fonc.2019.00249. eCollection 2019. PubMed PMID: 31024851; PubMed Central PMCID: PMC6465934.

12: Luanpitpong S, Janan M, Thumanu K, Poohadsuan J, Rodboon N, Klaihmon P, Issaragrisil S. Deciphering the Elevated Lipid via CD36 in Mantle Cell Lymphoma with Bortezomib Resistance Using Synchrotron-Based Fourier Transform Infrared Spectroscopy of Single Cells. Cancers (Basel). 2019 Apr 24;11(4). pii: E576. doi: 10.3390/cancers11040576. PubMed PMID: 31022903; PubMed Central PMCID: PMC6521097.

13: Heitmeier T, Sydykov A, Lukas C, Vroom C, Korfei M, Petrovic A, Klingel K, Günther A, Eickelberg O, Weissmann N, Ghofrani HA, Seeger W, Grimminger F, Schermuly RT, Meiners S, Kosanovic D. Altered proteasome function in right ventricular hypertrophy. Cardiovasc Res. 2019 Apr 24. pii: cvz103. doi: 10.1093/cvr/cvz103. [Epub ahead of print] PubMed PMID: 31020333.

14: Li YP, Zhang JG, Fang ZQ, Huang XR, Chen X, Li ZJ, Fang J. [Effect of Bushen Yanggu Decoction on Multidrug Resistance of Multiple Myeloma Cell Line KM3/BTZ]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Apr;27(2):482-488. doi: 10.19746/j.cnki.issn.1009-2137.2019.02.028. Chinese. PubMed PMID: 30998158.

15: Moschetti G, Amodeo G, Maftei D, Lattanzi R, Procacci P, Sartori P, Balboni G, Onnis V, Conte V, Panerai A, Sacerdote P, Franchi S. Targeting prokineticin system counteracts hypersensitivity, neuroinflammation, and tissue damage in a mouse model of bortezomib-induced peripheral neuropathy. J Neuroinflammation. 2019 Apr 17;16(1):89. doi: 10.1186/s12974-019-1461-0. PubMed PMID: 30995914; PubMed Central PMCID: PMC6471808.

16: Guo H, Huang B, Zhang L, Chen L, Xie Q, Liao Z, Huang S, Chen Y. Double Acceptor Block-Containing Copolymers with Deep HOMO Levels for Organic Solar Cells: Adjusting Carboxylate Substituent Position for Planarity. ACS Appl Mater Interfaces. 2019 May 1;11(17):15853-15860. doi: 10.1021/acsami.9b02212. Epub 2019 Apr 23. PubMed PMID: 30987420.

17: Homma T, Fujii J. An SOD1 deficiency aggravates proteasome inhibitor bortezomib-induced testicular damage in mice. Biochim Biophys Acta Gen Subj. 2019 Jun;1863(6):1108-1115. doi: 10.1016/j.bbagen.2019.04.005. Epub 2019 Apr 8. PubMed PMID: 30974160.

18: Fu Y, Liu X, Zhang F, Jiang S, Liu J, Luo Y. Bortezomib-inducible long non-coding RNA myocardial infarction associated transcript is an oncogene in multiple myeloma that suppresses miR-29b. Cell Death Dis. 2019 Apr 9;10(4):319. doi: 10.1038/s41419-019-1551-z. PubMed PMID: 30967527; PubMed Central PMCID: PMC6456577.

19: Brünnert D, Kraus M, Stühmer T, Kirner S, Heiden R, Goyal P, Driessen C, Bargou RC, Chatterjee M. Novel cell line models to study mechanisms and overcoming strategies of proteasome inhibitor resistance in multiple myeloma. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1666-1676. doi: 10.1016/j.bbadis.2019.04.003. Epub 2019 Apr 4. PubMed PMID: 30954557.

20: Gao N, Xing C, Wang H, Feng L, Zeng X, Mei L, Peng Z. pH-Responsive Dual Drug-Loaded Nanocarriers Based on Poly (2-Ethyl-2-Oxazoline) Modified Black Phosphorus Nanosheets for Cancer Chemo/Photothermal Therapy. Front Pharmacol. 2019 Mar 19;10:270. doi: 10.3389/fphar.2019.00270. eCollection 2019. PubMed PMID: 30941045; PubMed Central PMCID: PMC6433829.