5-trans-Prostaglandin E2
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MedKoo CAT#: 573746

CAS#: 36150-00-2

Description: 5-trans-Prostaglandin E2 accelerates fibrinolysis by enhancing plasminogen activation mediated by tissue-type plasminogen activator. It also inhibits platelet aggregation in human PRP.

Chemical Structure

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5-trans-Prostaglandin E2
CAS# 36150-00-2
Instruction

Theoretical Analysis

MedKoo Cat#: 573746
Name: 5-trans-Prostaglandin E2
CAS#: 36150-00-2
Chemical Formula: C20H32O5
Exact Mass: 352.23
Molecular Weight: 352.470
Elemental Analysis: C, 68.15; H, 9.15; O, 22.70

Price and Availability

Size Price Availability Quantity
1mg USD 235
5mg USD 525
10mg USD 860
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Synonym: 5,6-trans-Dinoprostone, 5,6-trans-PGE2, 5-trans-PGE2, 5-trans-Prostaglandin E2, Alprostadil impurity H, trans-Dinoprostone

IUPAC/Chemical Name: (E)-7-((1R,2R,3R)-3-Hydroxy-2-((E)-(3S)-3-hydroxyoct-1-enyl)-5-oxocyclopentyl)hept-5-enoic acid

InChi Key: XEYBRNLFEZDVAW-BRNHSORCSA-N

InChi Code: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4+,13-12+/t15-,16+,17+,19+/m0/s1

SMILES Code: CCCCC[C@@H](/C=C/[C@H]1[C@@H](CC(=O)[C@@H]1C/C=C/CCCC(=O)O)O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 352.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: McCluskey SV, Kirkham K, Munson JM. Stability of Alprostadil in 0.9% Sodium Chloride Stored in Polyvinyl Chloride Containers. Int J Pharm Compd. 2017 Mar-Apr;21(2):150-153. PubMed PMID: 28346210.

2: Ossorio-García L, Jiménez-Gallo D, Arjona-Aguilera C, Linares-Barrios M. Multimodal Treatment of Calciphylaxis With Sodium Thiosulfate, Alprostadil, and Hyperbaric Oxygen Therapy. Actas Dermosifiliogr. 2016 Oct;107(8):695-7. doi: 10.1016/j.ad.2016.04.004. Epub 2016 May 18. English, Spanish. PubMed PMID: 27208908.

3: Chen Y, Wan JX, Jiang DW, Fu BB, Cui J, Li GF. [Clinical efficacy and safety of sequential treatment with alprostadil and beraprost sodium for chronic renal failure induced by chronic glomerulonephritis]. Nan Fang Yi Ke Da Xue Xue Bao. 2013 Oct;33(10):1521-4. Chinese. PubMed PMID: 24144760.