SBI-115
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MedKoo CAT#: 555569

CAS#: 882366-16-7

Description: SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5. TGR5 contributes to hepatic cystogenesis by increasing cAMP and enhancing cholangiocyte proliferation; our data suggest that a TGR5 antagonist alone or concurrently with somatostatin receptor agonists represents a potential therapeutic approach in polycystic liver disease


Price and Availability

Size
Price

25mg
USD 150
200mg
USD 850
2g
USD 4950
Size
Price

50mg
USD 250
500mg
USD 1750
5g
USD 6950
Size
Price

100mg
USD 450
1g
USD 2850

SBI-115, purity > 98%, is in stock. The same day shipping after order received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555569
Name: SBI-115
CAS#: 882366-16-7
Chemical Formula: C14H13ClN2O4S
Exact Mass: 340.0285
Molecular Weight: 340.778
Elemental Analysis: C, 49.34; H, 3.85; Cl, 10.40; N, 8.22; O, 18.78; S, 9.41


Synonym: SBI-115; SBI 115; SBI115;

IUPAC/Chemical Name: 4-Pyrimidinecarboxylic acid, 5-chloro-2-(ethylsulfonyl)-, 3-methylphenyl ester

InChi Key: IJPXOPBVXVPPEW-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H13ClN2O4S/c1-3-22(19,20)14-16-8-11(15)12(17-14)13(18)21-10-6-4-5-9(2)7-10/h4-8H,3H2,1-2H3

SMILES Code: O=C(C1=NC(S(=O)(CC)=O)=NC=C1Cl)OC2=CC=CC(C)=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (MSDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Masyuk TV, Masyuk AI, Lorenzo Pisarello M, Howard BN, Huang BQ, Lee PY, Fung
X, Sergienko E, Ardecky RJ, Chung TDY, Pinkerton AB, LaRusso NF. TGR5 contributes
to hepatic cystogenesis in rodents with polycystic liver diseases through cyclic
adenosine monophosphate/Gαs signaling. Hepatology. 2017 Oct;66(4):1197-1218. doi:
10.1002/hep.29284. Epub 2017 Aug 26. PubMed PMID: 28543567; PubMed Central PMCID:
PMC5605412.