Thiethylperazine Maleate
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MedKoo CAT#: 565444

CAS#: 1179-69-7

Description: Thiethylperazine Maleate is a dopamine antagonist which blocks postsynaptic dopamine 2 (D2) receptors.


Chemical Structure

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Thiethylperazine Maleate
CAS# 1179-69-7

Theoretical Analysis

MedKoo Cat#: 565444
Name: Thiethylperazine Maleate
CAS#: 1179-69-7
Chemical Formula: C30H37N3O8S2
Exact Mass: 0.00
Molecular Weight: 631.760
Elemental Analysis: C, 57.04; H, 5.90; N, 6.65; O, 20.26; S, 10.15

Price and Availability

Size Price Availability Quantity
10mg USD 350 2 Weeks
50mg USD 850 2 Weeks
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Synonym: Toresten; Tresten; Torecan maleate; Torecan bimaleate; Torecan dimaleate; Thiethylperazine Maleate

IUPAC/Chemical Name: 2-Ethylsulfanyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine dimaleate

InChi Key: RVBRTNPNFYFDMZ-SPIKMXEPSA-N

InChi Code: InChI=1S/C22H29N3S2.2C4H4O4/c1-3-26-18-9-10-22-20(17-18)25(19-7-4-5-8-21(19)27-22)12-6-11-24-15-13-23(2)14-16-24;2*5-3(6)1-2-4(7)8/h4-5,7-10,17H,3,6,11-16H2,1-2H3;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-

SMILES Code: CN1CCN(CCCN2C3=C(C=CC=C3)SC4=CC=C(SCC)C=C24)CC1.O=C(O)/C=C\C(O)=O.O=C(O)/C=C\C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 631.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mendenhall A, Hoyt DB. Incompatibility of ketorolac tromethamine with haloperidol lactate and thiethylperazine maleate. Am J Hosp Pharm. 1994 Dec 1;51(23):2964. PubMed PMID: 7879809.

2: Corea RT. Dislocation of temporomandibular joints resulting from thiethylperazine maleate therapy. Ceylon Med J. 1984 Jun;29(2):117-8. PubMed PMID: 6529785.

3: LOVELACE FR, POE MF, DORNETTE WH. A CLINICAL EVALUATION OF THE ANTIEMETIC PROPERTIES OF THIETHYLPERAZINE MALEATE. Anesth Analg. 1963 Nov-Dec;42:653-7. PubMed PMID: 14071390.

4: GORDON ES, GOLDBERG M, CHOSY GJ. EVALUATION OF THIETHYLPERAZINE MALEATE. JAMA. 1963 Oct 5;186:61-2. PubMed PMID: 14046660.

5: DOBKIN AB, ROBIDOUX HJ Jr, ISRAEL JS. Circulatory response to tilt with hydroxyzine, thiethylperazine maleate, SA 97. and perphenazine. Anesth Analg. 1963 Mar-Apr;42:225-31. PubMed PMID: 14028223.