Bobcat339 HCl
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555567

CAS#: Unknown (HCl)

Description: Bobcat339 is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2). Bobcat339 has mid-μM inhibitor activity against TET1 and TET2, but does not inhibit the DNA methyltransferase, DNMT3a. These new molecular tools will be useful to the field of epigenetics and serve as a starting point for new therapeutics that target DNA methylation and gene transcription.


Price and Availability

Size
Price

50mg
USD 450
500mg
USD 1950
5g
USD 7450
Size
Price

100mg
USD 750
1g
USD 2950
Size
Price

200mg
USD 1150
2g
USD 4650

Bobcat339 HCl, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555567
Name: Bobcat339 HCl
CAS#: Unknown (HCl)
Chemical Formula: C16H13Cl2N3O
Exact Mass:
Molecular Weight: 334.2
Elemental Analysis: C, 57.50; H, 3.92; Cl, 21.21; N, 12.57; O, 4.79


Related CAS #: 2280037-51-4 (free base)    

Synonym: Bobcat339; Bobcat-339; Bobcat 339; Bobcat339 HCl; Bobcat339 hydrochloride

IUPAC/Chemical Name: 1-([1,1'-biphenyl]-3-yl)-4-amino-5-chloropyrimidin-2(1H)-one hydrochloride

InChi Key: ZOMPKMMOPYMRIB-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12ClN3O.ClH/c17-14-10-20(16(21)19-15(14)18)13-8-4-7-12(9-13)11-5-2-1-3-6-11;/h1-10H,(H2,18,19,21);1H

SMILES Code: O=C1N=C(N)C(Cl)=CN1C2=CC(C3=CC=CC=C3)=CC=C2.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Chua GNL, Wassarman KL, Sun H, Alp JA, Jarczyk EI, Kuzio NJ, Bennett MJ, Malachowsky BG, Kruse M, Kennedy AJ. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185. doi: 10.1021/acsmedchemlett.8b00474.eCollection 2019 Feb 14. PubMed PMID: 30783500; PubMed Central PMCID: PMC6378777.