Eprobemide
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MedKoo CAT#: 555563

CAS#: 87940-60-1

Description: Eprobemide was used as an antidepressant in Russia (under the brand name Бефол/Befol). It is a non-competitive reversible inhibitor of monoamine oxidase A that exhibits selective action on serotonin deamination. Eprobemide differs from moclobemide only in the linker that connects the morpholine fragment with the chlorobenzamide — moclobemide has two carbon atoms while eprobemide has three. Its registration was cancelled on December 30, 2003.


Price and Availability

Size
Price

100mg
USD 450
1g
USD 2650
Size
Price

200mg
USD 850
2g
USD 4650
Size
Price

500mg
USD 1650

Eprobemide, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555563
Name: Eprobemide
CAS#: 87940-60-1
Chemical Formula: C14H19ClN2O2
Exact Mass: 282.1135
Molecular Weight: 282.768
Elemental Analysis: C, 59.47; H, 6.77; Cl, 12.54; N, 9.91; O, 11.32


Synonym: Eprobemide,

IUPAC/Chemical Name: 4-Chloro-N-[3-(4-morpholinyl)propyl]benzamide

InChi Key: YYFGRAGNYHYWEZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C14H19ClN2O2/c15-13-4-2-12(3-5-13)14(18)16-6-1-7-17-8-10-19-11-9-17/h2-5H,1,6-11H2,(H,16,18)

SMILES Code: O=C(NCCCN1CCOCC1)C2=CC=C(Cl)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Michelsen MM, Pena A, Mygind ND, Frestad D, Gustafsson I, Hansen HS, Kastrup
J, Bech J, Høst N, Prescott E. Coronary Flow Velocity Reserve Assessed by
Transthoracic Doppler: The iPOWER Study: Factors Influencing Feasibility and
Quality. J Am Soc Echocardiogr. 2016 Jul;29(7):709-16. doi:
10.1016/j.echo.2016.02.011. Epub 2016 Mar 31. PubMed PMID: 27038514.

2: Cozzi A, Carpenedo R, Moroni F. Kynurenine hydroxylase inhibitors reduce
ischemic brain damage: studies with (m-nitrobenzoyl)-alanine (mNBA) and
3,4-dimethoxy-[-N-4-(nitrophenyl)thiazol-2yl]-benzenesulfonamide (Ro 61-8048) in
models of focal or global brain ischemia. J Cereb Blood Flow Metab. 1999
Jul;19(7):771-7. PubMed PMID: 10413032.

3: Tilakaratne N, Friedman E. Genomic responses to 5-HT1A or 5-HT2A/2C receptor
activation is differentially regulated in four regions of rat brain. Eur J
Pharmacol. 1996 Jun 27;307(2):211-7. PubMed PMID: 8832223.

4: Waleh NS, Brody MD, Knapp MA, Mendonca HL, Lord EM, Koch CJ, Laderoute KR,
Sutherland RM. Mapping of the vascular endothelial growth factor-producing
hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker.
Cancer Res. 1995 Dec 15;55(24):6222-6. PubMed PMID: 8521417.

5: Wouters W, Van Dun J, Laduron PM. Photoaffinity labelling of dopamine
receptors. Synthesis and binding characteristics of azapride. Eur J Biochem. 1984
Dec 3;145(2):273-8. PubMed PMID: 6548707.