ARN272
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MedKoo CAT#: 555562

CAS#: 488793-85-7

Description: ARN272 is a FAAH-like anandamide transporter (FLAT) inhibitor. ARN272 attenuates nausea-induced behaviour in rats, and vomiting in shrews (Suncus murinus). The anandamide transport inhibition by ARN272 tonically activates CB1 receptors and as such produces a type of indirect agonism to regulate toxin-induced nausea and vomiting.


Price and Availability

Size
Price

50mg
USD 250
500mg
USD 1850
Size
Price

100mg
USD 450
1g
USD 2950
Size
Price

200mg
USD 850
2g
USD 4950

ARN272, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555562
Name: ARN272
CAS#: 488793-85-7
Chemical Formula: C27H20N4O2
Exact Mass: 432.1586
Molecular Weight: 432.483
Elemental Analysis: C, 74.98; H, 4.66; N, 12.95; O, 7.40


Synonym: ARN272; ARN-272; ARN 272;

IUPAC/Chemical Name: 4-[[4-(4-hydroxyphenyl)-1-phthalazinyl]amino]-N-phenyl-benzamide

InChi Key: UPKNGUQNXSMHBE-UHFFFAOYSA-N

InChi Code: InChI=1S/C27H20N4O2/c32-22-16-12-18(13-17-22)25-23-8-4-5-9-24(23)26(31-30-25)28-21-14-10-19(11-15-21)27(33)29-20-6-2-1-3-7-20/h1-17,32H,(H,28,31)(H,29,33)

SMILES Code: O=C(NC1=CC=CC=C1)C2=CC=C(NC3=NN=C(C4=CC=C(O)C=C4)C5=C3C=CC=C5)C=C2


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: O'Brien LD, Limebeer CL, Rock EM, Bottegoni G, Piomelli D, Parker LA.
Anandamide transport inhibition by ARN272 attenuates nausea-induced behaviour in
rats, and vomiting in shrews (Suncus murinus). Br J Pharmacol. 2013
Nov;170(5):1130-6. doi: 10.1111/bph.12360. PubMed PMID: 23991698; PubMed Central
PMCID: PMC3949659.

2: Fu J, Bottegoni G, Sasso O, Bertorelli R, Rocchia W, Masetti M, Guijarro A,
Lodola A, Armirotti A, Garau G, Bandiera T, Reggiani A, Mor M, Cavalli A,
Piomelli D. A catalytically silent FAAH-1 variant drives anandamide transport in
neurons. Nat Neurosci. 2011 Nov 20;15(1):64-9. doi: 10.1038/nn.2986. Erratum in:
Nat Neurosci. 2013 Dec;16(12):1907. PubMed PMID: 22101642; PubMed Central PMCID:
PMC3245783.