Pamatolol

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584993

CAS#: 59110-35-9

Description: Pamatolol is a cardioselective beta adrenoceptor blocking drug.

Chemical Structure

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Pamatolol
CAS# 59110-35-9
Instruction

Theoretical Analysis

MedKoo Cat#: 584993
Name: Pamatolol
CAS#: 59110-35-9
Chemical Formula: C16H26N2O4
Exact Mass: 310.19
Molecular Weight: 310.394
Elemental Analysis: C, 61.91; H, 8.44; N, 9.03; O, 20.62

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Pamatolol, Pamatololum

IUPAC/Chemical Name: (2-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl) ethyl)carbamic acid methyl ester

InChi Key: UGENBJKPPGFFAT-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H26N2O4/c1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3/h4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20)

SMILES Code: O=C(OC)NCCC1=CC=C(OCC(O)CNC(C)C)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 310.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Johansson B. Effects of atenolol, metroprolol, and pamatolol on cardiac and vascular beta-adrenoceptors in the rat. J Cardiovasc Pharmacol. 1979 May-Jun;1(3):287-98. PubMed PMID: 94397.

2: Carruthers SG, Hosler JP, Pentikainen P, Azarnoff DL. Pamatolol: phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug. Clin Pharmacol Ther. 1978 Aug;24(2):168-74. PubMed PMID: 28193.

3: Hoffmann KJ, Skånberg I, Borg KO. Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist. Eur J Drug Metab Pharmacokinet. 1979;4(3):163-73. PubMed PMID: 43252.

4: Hoffmann K. Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol. Acta Pharm Suec. 1979;16(2):160. PubMed PMID: 38629.

5: Carruthers SG, Pentikainen P, Hosler JP, Azarnoff DL. Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker. Clin Pharmacol Ther. 1979 Dec;26(6):682-5. PubMed PMID: 40725.

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8: Ban T, Sada S, Takahashi Y, Sada H, Fujita T. Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1985 Mar;329(1):77-85. PubMed PMID: 2582279.

9: Ahrén B, Lundquist I. Effects of selective and non-selective beta-adrenergic agents on insulin secretion in vivo. Eur J Pharmacol. 1981 Apr 24;71(1):93-104. PubMed PMID: 6113155.

10: Hedberg A, Mattsson H. Beta adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle. J Pharmacol Exp Ther. 1981 Dec;219(3):798-808. PubMed PMID: 6117657.

11: Mattsson H, Andersson T, Carlsson E, Hedberg A, Lundgren B, Olsson T. beta 1-and beta 2-adrenoceptor stimulatory effects of prenalterol. Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(4):302-8. PubMed PMID: 6132344.

12: Carlsöö B, Danielsson A, Henriksson R. Beta 1- and beta 2-adrenoceptor-mediated secretion of amylase from incubated rat parotid gland. Acta Physiol Scand. 1984 Mar;120(3):429-35. PubMed PMID: 6204505.

13: Gyllenhaal O, Vessman J. Gas chromatography with nitrogen-selective detection of metoprolol from human plasma after reaction with phosgene. J Chromatogr. 1983 Mar 11;273(1):129-39. PubMed PMID: 6853642.