Pamatolol

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MedKoo CAT#: 584993

CAS#: 59110-35-9

Description: Pamatolol is a cardioselective beta adrenoceptor blocking drug.


Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-07-11. Prices are subject to change without notice.

Pamatolol is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584993
Name: Pamatolol
CAS#: 59110-35-9
Chemical Formula: C16H26N2O4
Exact Mass: 310.1893
Molecular Weight: 310.394
Elemental Analysis: C, 61.91; H, 8.44; N, 9.03; O, 20.62


Synonym: Pamatolol, Pamatololum

IUPAC/Chemical Name: (2-(4-(2-Hydroxy-3-((1-methylethyl)amino)propoxy)phenyl) ethyl)carbamic acid methyl ester

InChi Key: UGENBJKPPGFFAT-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H26N2O4/c1-12(2)18-10-14(19)11-22-15-6-4-13(5-7-15)8-9-17-16(20)21-3/h4-7,12,14,18-19H,8-11H2,1-3H3,(H,17,20)

SMILES Code: O=C(OC)NCCC1=CC=C(OCC(O)CNC(C)C)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Johansson B. Effects of atenolol, metroprolol, and pamatolol on cardiac and vascular beta-adrenoceptors in the rat. J Cardiovasc Pharmacol. 1979 May-Jun;1(3):287-98. PubMed PMID: 94397.

2: Carruthers SG, Hosler JP, Pentikainen P, Azarnoff DL. Pamatolol: phase I evaluation of the pharmacodynamics of a cardioselective beta adrenoceptor blocking drug. Clin Pharmacol Ther. 1978 Aug;24(2):168-74. PubMed PMID: 28193.

3: Hoffmann KJ, Skånberg I, Borg KO. Species differences in the metabolism of pamatolol, a cardioselective beta--adrenoceptor antagonist. Eur J Drug Metab Pharmacokinet. 1979;4(3):163-73. PubMed PMID: 43252.

4: Hoffmann K. Studies on the metabolism of the beta-adrenoceptor antagonists alprenolol, metoprolol and pamatolol. Acta Pharm Suec. 1979;16(2):160. PubMed PMID: 38629.

5: Carruthers SG, Pentikainen P, Hosler JP, Azarnoff DL. Kinetics of pamatolol, a cardioselective beta adrenoreceptor blocker. Clin Pharmacol Ther. 1979 Dec;26(6):682-5. PubMed PMID: 40725.

6: Björgell P, Belfrage P. Characteristics of the lipolytic beta-adrenergic receptors in hamster adipocytes. Biochim Biophys Acta. 1982 Oct 14;713(1):80-5. PubMed PMID: 6128033.

7: Jackson CD, Fishbein L. A toxicological review of beta-adrenergic blockers. Fundam Appl Toxicol. 1986 Apr;6(3):395-422. Review. PubMed PMID: 2870945.

8: Ban T, Sada S, Takahashi Y, Sada H, Fujita T. Effects of para-substituted beta-adrenoceptor blocking agents and methyl-substituted phenoxypropanolamine derivatives on maximum upstroke velocity of action potential in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1985 Mar;329(1):77-85. PubMed PMID: 2582279.

9: Ahrén B, Lundquist I. Effects of selective and non-selective beta-adrenergic agents on insulin secretion in vivo. Eur J Pharmacol. 1981 Apr 24;71(1):93-104. PubMed PMID: 6113155.

10: Hedberg A, Mattsson H. Beta adrenoceptor interaction of full and partial agonists in the cat heart and soleus muscle. J Pharmacol Exp Ther. 1981 Dec;219(3):798-808. PubMed PMID: 6117657.

11: Mattsson H, Andersson T, Carlsson E, Hedberg A, Lundgren B, Olsson T. beta 1-and beta 2-adrenoceptor stimulatory effects of prenalterol. Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(4):302-8. PubMed PMID: 6132344.

12: Carlsöö B, Danielsson A, Henriksson R. Beta 1- and beta 2-adrenoceptor-mediated secretion of amylase from incubated rat parotid gland. Acta Physiol Scand. 1984 Mar;120(3):429-35. PubMed PMID: 6204505.

13: Gyllenhaal O, Vessman J. Gas chromatography with nitrogen-selective detection of metoprolol from human plasma after reaction with phosgene. J Chromatogr. 1983 Mar 11;273(1):129-39. PubMed PMID: 6853642.