WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565378
Description: JSI287 is a ERK inhibitor, alleviating IMQ-induced mice skin lesions through ERK/IL-17 signaling pathway
MedKoo Cat#: 565378
Chemical Formula: C26H22Cl2FN5O2
Exact Mass: 525.1135
Molecular Weight: 526.39
Elemental Analysis: C, 59.33; H, 4.21; Cl, 13.47; F, 3.61; N, 13.30; O, 6.08
This product is not in stock, which may be available by custom synthesis.
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Synonym: JSI-287; JSI 287; JSI287
IUPAC/Chemical Name: (S)-7-(2-((2-chloro-4-fluorophenyl)amino)-5-methylpyrimidin-4-yl)-2-(1-(3-chlorophenyl)-2-hydroxyethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one
InChi Key: JHGJUQUMQAHXRV-HSZRJFAPSA-N
InChi Code: InChI=1S/C26H22Cl2FN5O2/c1-15-12-30-26(31-21-6-5-19(29)11-20(21)28)32-24(15)17-10-22-25(36)34(8-7-33(22)13-17)23(14-35)16-3-2-4-18(27)9-16/h2-6,9-13,23,35H,7-8,14H2,1H3,(H,30,31,32)/t23-/m1/s1
SMILES Code: O=C1C2=CC(C3=NC(NC4=CC=C(F)C=C4Cl)=NC=C3C)=CN2CCN1[C@@H](C5=CC=CC(Cl)=C5)CO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 526.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Huang X, Yu P, Liu M, Deng Y, Dong Y, Liu Q, Zhang J, Wu T. ERK inhibitor JSI287 alleviates imiquimod-induced mice skin lesions by ERK/IL-17 signaling pathway. Int Immunopharmacol. 2019 Jan;66:236-241. doi: 10.1016/j.intimp.2018.11.031. Epub 2018 Nov 24. PubMed PMID: 30481683.