P-1946

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584969

CAS#: 449806-40-0

Description: P-1946 is an HIV-1 protease inhibitor.


Price and Availability

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Price

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P-1946 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584969
Name: P-1946
CAS#: 449806-40-0
Chemical Formula: C29H41N5O6S
Exact Mass: 587.2778
Molecular Weight: 587.736
Elemental Analysis: C, 59.26; H, 7.03; N, 11.92; O, 16.33; S, 5.45


Synonym: P-1946; P1946; P 1946

IUPAC/Chemical Name: Carbamic acid, ((1S)-2-(((5S)-5-(((4-aminophenyl)sulfonyl)(2-methylpropyl)amino)-6-hydroxyhexyl)amino)-1-(1H-indol-3-ylmethyl)-2-oxoethyl)-, methyl ester

InChi Key: KLFMLSLUVACAEA-HOFKKMOUSA-N

InChi Code: InChI=1S/C29H41N5O6S/c1-20(2)18-34(41(38,39)24-13-11-22(30)12-14-24)23(19-35)8-6-7-15-31-28(36)27(33-29(37)40-3)16-21-17-32-26-10-5-4-9-25(21)26/h4-5,9-14,17,20,23,27,32,35H,6-8,15-16,18-19,30H2,1-3H3,(H,31,36)(H,33,37)/t23-,27-/m0/s1

SMILES Code: O=C(OC)N[C@@H](CC1=CNC2=C1C=CC=C2)C(NCCCC[C@H](N(S(=O)(C3=CC=C(N)C=C3)=O)CC(C)C)CO)=O


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934.99.90.01


References

1: Sévigny G, Stranix B, Tian B, Dubois A, Sauvé G, Petropoulos C, Lie Y, Hellmann N, Conway B, Yelle J. Antiviral activity and cross-resistance profile of P-1946, a novel human immunodeficiency virus type 1 protease inhibitor. Antiviral Res. 2006 Jun;70(2):17-20. Epub 2006 Jan 20. PubMed PMID: 16473417.

2: Corrections and clarifications. Science. 1993 Feb 5;259(5096):747. PubMed PMID: 17809322.

3: Benedetti S, Casamenti V, Benedetti M. Long-term endothelial changes in phakic eyes after Artisan intraocular lens implantation to correct myopia: five-year study. J Cataract Refract Surg. 2007 May;33(5):784-90. PubMed PMID: 17466848.