nAS-E
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MedKoo CAT#: 565338

CAS#: 92-78-4

Description: nAS-E is an inhibitor of the KIX-KID interaction and CREB-mediated gene transcription.

Chemical Structure

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nAS-E
CAS# 92-78-4
Product data Instruction

Theoretical Analysis

MedKoo Cat#: 565338
Name: nAS-E
CAS#: 92-78-4
Chemical Formula: C17H12ClNO2
Exact Mass: 297.06
Molecular Weight: 297.738
Elemental Analysis: C, 68.58; H, 4.06; Cl, 11.91; N, 4.70; O, 10.75

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Naphthol AS-E; nAS-E; nAS E

IUPAC/Chemical Name: N-(4-Chlorophenyl)-3-hydroxy-2-naphthamide

InChi Key: OHAXNCGNVGGWSO-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H12ClNO2/c18-13-5-7-14(8-6-13)19-17(21)15-9-11-3-1-2-4-12(11)10-16(15)20/h1-10,20H,(H,19,21)

SMILES Code: O=C(NC1=CC=C(Cl)C=C1)C2=C(O)C=C3C=CC=CC3=C2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:
Product Data
Instruction:
View handling instruction
Biological target: Naphthol AS-E is a potent and cell-permeable inhibitor of KIX-KID interaction.
In vitro activity: This study describes the discovery of naphthol AS-E (1) as a cell-permeable small-molecule inhibitor of the KIX–KID interaction by using a novel Renilla luciferase complementation assay. Reference: Chembiochem. 2009 Nov 23;10(17):2721-4. https://pubmed.ncbi.nlm.nih.gov/19810079/
In vivo activity: In addition, the in vivo effect of nAS-E in protecting against breast cancer-induced osteolysis was evaluated in mice. These results indicated that nAS-E could reverse bone loss induced by MDA-MB-231 tumour. Reference: J Cell Mol Med. 2019 Feb;23(2):1224-1234. https://pubmed.ncbi.nlm.nih.gov/30461194/

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.7 139.96

Preparing Stock Solutions

The following data is based on the product molecular weight 297.74 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Yang Q, Tang J, Cao J, Liu F, Fu M, Xue B, Zhou A, Chen S, Liu J, Zhou Y, Shi Y, Peng W, Chen X. SARS-CoV-2 infection activates CREB/CBP in cellular cyclic AMP-dependent pathways. J Med Virol. 2023 Jan;95(1):e28383. doi: 10.1002/jmv.28383. PMID: 36477795; PMCID: PMC9877775. 2. Li BX, Xiao X. Discovery of a small-molecule inhibitor of the KIX-KID interaction. Chembiochem. 2009 Nov 23;10(17):2721-4. doi: 10.1002/cbic.200900552. PMID: 19810079; PMCID: PMC4214275. 3. Kuang Q, Liang Y, Zhuo Y, Cai Z, Jiang F, Xie J, Zheng Y, Zhong W. The ALDOA Metabolism Pathway as a Potential Target for Regulation of Prostate Cancer Proliferation. Onco Targets Ther. 2021 May 24;14:3353-3366. doi: 10.2147/OTT.S290284. PMID: 34079281; PMCID: PMC8163754. 4. Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2019 Feb;23(2):1224-1234. doi: 10.1111/jcmm.14024. Epub 2018 Nov 20. PMID: 30461194; PMCID: PMC6349349.
In vitro protocol: 1. Yang Q, Tang J, Cao J, Liu F, Fu M, Xue B, Zhou A, Chen S, Liu J, Zhou Y, Shi Y, Peng W, Chen X. SARS-CoV-2 infection activates CREB/CBP in cellular cyclic AMP-dependent pathways. J Med Virol. 2023 Jan;95(1):e28383. doi: 10.1002/jmv.28383. PMID: 36477795; PMCID: PMC9877775. 2. Li BX, Xiao X. Discovery of a small-molecule inhibitor of the KIX-KID interaction. Chembiochem. 2009 Nov 23;10(17):2721-4. doi: 10.1002/cbic.200900552. PMID: 19810079; PMCID: PMC4214275.
In vivo protocol: 1. Kuang Q, Liang Y, Zhuo Y, Cai Z, Jiang F, Xie J, Zheng Y, Zhong W. The ALDOA Metabolism Pathway as a Potential Target for Regulation of Prostate Cancer Proliferation. Onco Targets Ther. 2021 May 24;14:3353-3366. doi: 10.2147/OTT.S290284. PMID: 34079281; PMCID: PMC8163754. 2. Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2019 Feb;23(2):1224-1234. doi: 10.1111/jcmm.14024. Epub 2018 Nov 20. PMID: 30461194; PMCID: PMC6349349.

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1: Jiang M, Yan Y, Yang K, Liu Z, Qi J, Zhou H, Qian N, Zhou Q, Wang T, Xu X, Xiao X, Deng L. Small molecule nAS-E targeting cAMP response element binding protein (CREB) and CREB-binding protein interaction inhibits breast cancer bone metastasis. J Cell Mol Med. 2019 Feb;23(2):1224-1234. doi: 10.1111/jcmm.14024. Epub 2018 Nov 20. PubMed PMID: 30461194; PubMed Central PMCID: PMC6349349.